Results 41 to 50 of about 1,703,563 (303)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

How microplastics affect chiral illicit drug methamphetamine in aquatic food chain? From green alga (Chlorella pyrenoidosa) to freshwater snail (Cipangopaludian cathayensis)

Environment International, 2020
The biological impacts of microplastics on many organisms have been well documented. However, the combined effects of microplastics and chiral chemicals on the aquatic food chain are less clear.
Han Qu, Ruixue Ma, Holly Barrett, Bin Wang, Jiajun Han, Fang Wang, Pin Chen, Wei Wang, Guilong Peng, Gang Yu   +9 more
doaj   +1 more source

Prioritizing toxicological research on emerging contaminants or issues of concern: Identification, response, timing, and teamwork [PDF]

, 2021
Presented by: Suzanne Fenton – research scientist at National Institute of Environmental Health Sciences, suzanne.fenton@nih.gov Co-authors: Blystone CR, Jahnke GD, Lunn RM, Smith-Roe SL, Mutlu E Abstract: Public health is affected by emerging ...
Fenton, Suzanne
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Investigating Short-Chain Chlorinated Paraffins (SCCPs) in China: A Review of Occurrences, Determination Techniques, Human Exposure Routes, Toxicity, and Risk Assessments

Toxics
Chlorinated paraffins (CPs) are recognized as a novel class of persistent organic pollutants (POPs) and are categorized into short- (SCCPs, C10–13), medium- (MCCPs, C14–17), and long- (LCCPs, C≥18) chain CPs considering the carbon-chain length.
Jiangbo Niu, Zixuan Qiu, Jiaying Yang, Shuren Liu, Lili Niu, Zili Guo, Shuang Zhang, Shuduan Mao, Weiping Liu   +8 more
doaj   +1 more source

Process Optimization and Structure Characterization of Jackfruit Seed Dietary Fiber Modified by High Temperature Cooking Combined with Ultrasonic Enzymatic Method

Shipin gongye ke-ji, 2023
The jackfruit seed dietary fiber was modified by high temperature cooking combined with ultrasonic enzymatic method. Single factor combined with response surface method was applied to optimize the modification process conditions. The structure of soluble
Dan LI, Xiumei WANG, Jie LIANG, Tao LIU, Guorong LIN, Lixia WANG, Xinyi ZHENG   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Toxicity and transcriptome sequencing analyses of nanoplastics combined with acetaminophen on zebrafish bone development

Ecotoxicology and Environmental Safety
Congenital spinal malformation, a significant birth defect with unclear etiology, has been increasingly associated with environmental factors in recent studies.
Yuwei Gao, Wenting Shen, Zixin Xu, Yiming Zhang, Xinru Zhao, Hongyan Zhang, Xianlei Gao, Zhenzhen Jia   +7 more
doaj   +1 more source

Occurrence and discharge of pharmaceuticals and personal care products in dewatered sludge from WWTPs in Beijing and Shenzhen

Emerging Contaminants, 2016
This study mainly focused on the occurrence of pharmaceutical and personal care products (PPCPs) in sewage dewatered sludge and their discharges through sludge disposal from wastewater treatment plants (WWTPs).
Rui Dong, Gang Yu, Yuntao Guan, Bin Wang, Jun Huang, Shubo Deng, Yujue Wang   +6 more
doaj   +1 more source

Manganese: A New Emerging Contaminant in the Environment [PDF]

, 2012
The environment is composed of the atmosphere, earth and water. According to the World Health Organization, more than 100,000 chemicals are released into the global ambient every year as a consequence of their production, use and disposal. The fate of a chemical substance depends on its chemical application and physical-chemical properties, in ...
Pinsino A, Matranga V, Roccheri MC
openaire   +2 more sources