Results 61 to 70 of about 1,703,563 (303)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Assessment of POPs in foods from western China: Machine learning insights into risk and contamination drivers

Environment International
Persistent organic pollutants (POPs), including PCDD/Fs, PCBs, and PBDEs, are major environmental and food safety concerns due to their bioaccumulative and toxic properties. However, comprehensive research on the concentrations and influencing factors of
Dasheng Lu, Yuanjie Lin, Sunyang Le, Yuhang Chen, Chao Feng, Zixin Qian, Guoquan Wang, Jingguang Li, Ping Xiao   +8 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

A biochar-based coated urea for enhanced nitrogen utilization in wheat farming: Field performance, soil microbial response and life cycle assessment

Industrial Crops and Products
Nitrogen use efficiency (NUE) of conventional urea remains low, leading to significant economic and environmental challenges. While biodegradable polymer-coated slow-release fertilizers offer a promising alternative, their performance is often hampered ...
Shumian Jiang, Aosheng Bai, Qinglong Chen, Xu Zhao, Chang Dong, Yan Zhang, Zhen Qiu, Cheng Fu, Yongfu Li, Yanjiang Cai, Bing Yu   +10 more
doaj   +1 more source

Electrospun nanofiber membranes for the control of micro/nanoplastics in the environment

, 2022
In recent years, the environmental pollution caused by micro/nanoplastics (MNPs) has increased. As a result of their negative impact on human health and the environment, MNPs have emerged as new scientific challenges.
Pervez, Md. Nahid, Buonerba, Antonio, Belgiorno, Vincenzo, Zhao, Yaping, Naddeo, Vincenzo, Mishu, Monira Rahman, Figoli, Alberto, Talukder, Md Eman, Stylios, George K., Cai, Yingjie, Zarra, Tiziano, Hasan, Shadi W., Pervez, N.   +12 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Behaviour of emerging contaminants in sewage sludge after anaerobic digestion [PDF]

, 2016
Nowadays, there is an increasing concern over the presence of contaminants in the aquatic environment, where they can be introduced from wastewater after their incomplete removal in the treatment plants.
Sánchez-Ramírez, J. E., Morales, E., Hernandez, Felix, Boix Sales, Clara, Sancho, Juan V, Pastor, L., Hernández Hernández, Félix, Ibáñez, Maria, Fabregat-Safont, David   +8 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source