Results 101 to 110 of about 1,561,128 (291)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Struggles and resilience: thalassemia patients navigating COVID-19 in Bangladesh

Journal of Rare Diseases
Purpose Bangladesh is located in the thalassemia-prone region geographically. Thalassemia patients need lifetime interdisciplinary care for their well-being.
Farhin Islam, Senjuti Seemanta, Sonia Rezina, Afsana Mehrab, Enayetur Raheem, Mohammad Sorowar Hossain   +5 more
doaj   +1 more source

Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection

mSphere, 2019
Dengue is caused by infection with any one of four dengue viruses (DENV); the risk of severe disease appears to be enhanced by the cross-reactive or subneutralizing levels of antibody from a prior DENV infection.
Candice Y. Y. Chan, John Zhong Heng Low, Esther Shuyi Gan, Eugenia Ziying Ong, Summer Li-Xin Zhang, Hwee Cheng Tan, Xiaoran Chai, Sujoy Ghosh, Eng Eong Ooi, Kuan Rong Chan   +9 more
doaj   +1 more source

Emerging diseases of goats in Malaysia [PDF]

, 2010
Malaysia is aggressively reviving its sluggish small ruminant industry via imports of high and good quality productive goats. However, certain diseases especially the ones which take an insidious course may be missed (rather long incubation period ...
Allaudin, Zeenathul Nazariah, Arshad, Aziz, Awang Isa, Kamarudin, Goriman Khan, Mohd Azam Khan, Koran, Ragavan, Mohamed Mustapha, Noordin, Shamsudin, Shahirudin   +6 more
core  

Emerging Zoonotic Diseases [PDF]

Emerging Infectious Diseases, 2001
Gail R. Hansen, Jack Woodall, Corrie Brown, Nancy Jaax, Tracy McNamara, Alfonso Ruiz   +5 more
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Electron transport chain capacity expands yellow fever vaccine immunogenicity

EMBO Molecular Medicine
Vaccination has successfully controlled several infectious diseases although better vaccines remain desirable. Host response to vaccination studies have identified correlates of vaccine immunogenicity that could be useful to guide development and ...
Darren ZL Mok, Danny JH Tng, Jia Xin Yee, Valerie SY Chew, Christine YL Tham, Justin SG Ooi, Hwee Cheng Tan, Summer L Zhang, Lowell Z Lin, Wy Ching Ng, Lavanya Lakshmi Jeeva, Ramya Murugayee, Kelvin K-K Goh, Tze-Peng Lim, Liang Cui, Yin Bun Cheung, Eugenia Z Ong, Kuan Rong Chan, Eng Eong Ooi, Jenny G Low   +19 more
doaj   +1 more source

Exploring Risk Perceptions of Emerging Infectious Diseases [PDF]

, 2009
This thesis is about risk perception of infectious diseases, with a special focus on the emerging infections SARS and avian influenza, and explores potential determinants of risk perception and the relation of risk perception with precautionary ...
Zwart, O. (Onno) de
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Performance of the Trioplex real-time RT-PCR assay for detection of Zika, dengue, and chikungunya viruses

Nature Communications, 2018
The Trioplex real-time RT-PCR assay was developed for detection of Zika virus infections in areas with dengue and chikungunya transmission. Here, Santiago et al.
Gilberto A. Santiago, Jesús Vázquez, Sean Courtney, Katia Y. Matías, Lauren E. Andersen, Candimar Colón, Angela E. Butler, Rebecca Roulo, John Bowzard, Julie M. Villanueva, Jorge L. Muñoz-Jordan   +10 more
doaj   +1 more source