Results 121 to 130 of about 1,578,591 (309)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus

Communications Biology
Bats as the only flying mammals incur a high metabolic cost during extended powered flight, which results in febrile-like temperatures without injury. Herein, we investigate the in vivo heat shock response (HSR) in the cave nectar bat Eonycteris spelaea.
Leon J. W. Tang, Akshamal M. Gamage, Wei Lun Ng, Wan Rong Sia, Randy Foo, Ning Yuan Shen, Wharton O. Y. Chan, Shiwei Chen, Vivian Chih-Wei Chen, Beng Lee Lim, Chee Wah Tan, Lin-Fa Wang   +11 more
doaj   +1 more source

Emerging Diseases/Viruses Prevention, Control, Surveillance, and One Health. [PDF]

Trop Med Infect Dis, 2023
Simonin Y.
europepmc   +1 more source

[Emerging noninfectious diseases].

Revista panamericana de salud publica = Pan American journal of public health, 2009
In recent years, emerging diseases were defined as being infectious, acquiring high incidence, often suddenly, or being a threat or an unexpected phenomenon. This study discusses the hallmarks of emerging diseases, describing the existence of noninfectious emerging diseases, and elaborating on the advantages of defining noninfectious diseases as ...
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Emerging and Re-Emerging Diseases Caused by Badnaviruses. [PDF]

Pathogens, 2023
Ishwara Bhat A, Selvarajan R, Balasubramanian V.   +2 more
europepmc   +1 more source

Ontological representation of CDC Active Bacterial Core Surveillance Case Reports [PDF]

, 2014
The Center for Disease Control and Prevention’s Active Bacterial Core Surveillance (CDC ABCs) Program is a collaborative effort betweeen the CDC, state health departments, laboratories, and universities to track invasive bacterial pathogens of particular
Cowell, Lindsay G., Goldfain, Albert, Smith, Barry   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Distinct functional connectivity patterns in myalgic encephalomyelitis and long COVID patients during cognitive fatigue: a 7 Tesla task-fMRI study

Journal of Translational Medicine
Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and long COVID are chronic debilitating illnesses featuring fatigue, post-exertional malaise (PEM) and neurocognitive deficits.
Maira Inderyas, Kiran Thapaliya, Sonya Marshall-Gradisnik, Leighton Barnden   +3 more
doaj   +1 more source

The Need for Emerging Diseases Curricula: A Case Study of Mpox. [PDF]

PRiMER, 2022
Stumbar SE, Nusynowitz J, Jamneshan L, Samuels M, Garba NA.   +4 more
europepmc   +1 more source