Results 141 to 150 of about 4,319,558 (311)

Is Better Standardization of Therapeutic Antibody Quality in Emerging Diseases Epidemics Possible? [PDF]

Front Immunol, 2022
Ravlić S, Hećimović A, Kurtović T, Ivančić Jelečki J, Forčić D, Slović A, Kurolt IC, Mačak Šafranko Ž, Mušlin T, Rnjak D, Jakšić O, Sorić E, Džepina G, Đaković Rode O, Kujavec Šljivac K, Vuk T, Jukić I, Markotić A, Halassy B.   +18 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

National Center for Emerging and Zoonotic Infectious Diseases accomplishments 2019

CDC\u2019s National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) works 24/7 to protect the United States from domestic and global public health threats. This report highlights our work in 2019.

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Performance and challenges of malaria rapid diagnostic tests in endemic regions of Africa

Scientific Reports
Rapid diagnostic tests (RDTs) have revolutionized malaria diagnosis, playing a crucial role in improving timely treatment and supporting surveillance efforts, especially in resource-limited settings.
Fiyinfoluwa Demilade Ojeniyi, Adeola Oluwakemi Ayoola, Olajumoke Ibitoye, Oluyinka Oladele Opaleye, Olugbenga Adekunle Olowe, Leonard Ona Ehigie, Bolaji N. Thomas, Olusola Ojurongbe   +7 more
doaj   +1 more source

Structural and Phylogenetic Analysis of CXCR4 Protein Reveals New Insights into Its Role in Emerging and Re-Emerging Diseases in Mammals. [PDF]

Vaccines (Basel), 2023
Naheed F, Mumtaz R, Shabbir S, Jamil A, Asif AR, Rahman A, Ahmad HI, Essa M, Akhtar H, Mahmoud SF, Alghamdi FO, Amari HAA, Chen J.   +12 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Hunter's tropical medicine and emerging infectious diseases /

New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules . all significant, recent developments in the fast-changing field of tropical medicine.
Ryan, Edward T.,editor., Aronson, Naomi,editor., Solomon, Tom,editor., Hill, David R.(David Russell),editor., Endy, Timothy P.,editor.   +4 more
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Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases. [PDF]

Biomolecules, 2022
Rizvi SAA, Einstein GP, Tulp OL, Sainvil F, Branly R.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

National Center for Emerging and Zoonotic Infectious Diseases accomplishments 2021

CDC\u2019s National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) protects people from domestic and global public health threats.

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