Results 131 to 140 of about 1,578,591 (309)

The case for launch of an international DNA-based birth cohort study [PDF]

, 2011
The global health agenda beyond 2015 will inevitably need to broaden its focus from mortality reduction to the social determinants of deaths, growing inequities among children and mothers, and ensuring the sustainability of the progress made against the ...
Aulchenko, Yurii, Baqui, Abdullah H, Bhutta, Zulfiqar A, Campbell, Harry, Chopra, Mickey, Edmond, Karen, Horta, Bernardo L, Klugman, Keith P, Lanata, Claudio F, Madhi, Shabir A, Nair, Harish, Qureshi, Zeshan, Rubens, Craig, Rudan, Igor, Theodoratou, Evropi, Victora, Cesar G, Wang, Wei, Weber, Martin W, Wilson, James F, Zgaga, Lina   +19 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Impaired brain intrinsic connectivity in long COVID during cognitive exertion revealed by independent component analysis

Scientific Reports
Cognitive dysfunction is a symptom of Long COVID. To characterize functional connectivity changes that may contribute to cognitive dysfunction in Long COVID (LCov), two consecutive 450 s functional magnetic resonance imaging (fMRI) scans (Runs 1 and 2 ...
Leighton Barnden, James Baraniuk, Maira Inderyas, Natalie Eaton-Fitch, Sonya Marshall-Gradisnik, Kiran Thapaliya   +5 more
doaj   +1 more source

Neglecting emerging diseases - monkeypox is the latest price of a costly default. [PDF]

Med, 2022
Titanji BK.
europepmc   +1 more source

Approche intégrée des maladies émergentes à transmission vectorielle et changements mondiaux : exemple et perspective [PDF]

, 2009
Vector-borne diseases (e.g., bluetongue or Rift Valley fever) are very sensitive to environmental changes. As such, they are excellent models to study disease emergence in a changing world, with more intense commercial exchanges, climate changes, and ...
Aumont, Gilles, De La Rocque, Stéphane, Gouro, Abdoulaye, Lancelot, Renaud   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Special Issue "Emerging Diseases/Viruses: Prevention, Control, Surveillance, and One Health". [PDF]

Trop Med Infect Dis, 2022
Simonin Y.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Role of immunity landscape in global risk assessment of re-emerging diseases. [PDF]

Lancet Infect Dis, 2023
Pandey A, Galvani AP.
europepmc   +1 more source