Results 101 to 110 of about 822,085 (315)

Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection

mSphere, 2019
Dengue is caused by infection with any one of four dengue viruses (DENV); the risk of severe disease appears to be enhanced by the cross-reactive or subneutralizing levels of antibody from a prior DENV infection.
Candice Y. Y. Chan, John Zhong Heng Low, Esther Shuyi Gan, Eugenia Ziying Ong, Summer Li-Xin Zhang, Hwee Cheng Tan, Xiaoran Chai, Sujoy Ghosh, Eng Eong Ooi, Kuan Rong Chan   +9 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus

Communications Biology
Bats as the only flying mammals incur a high metabolic cost during extended powered flight, which results in febrile-like temperatures without injury. Herein, we investigate the in vivo heat shock response (HSR) in the cave nectar bat Eonycteris spelaea.
Leon J. W. Tang, Akshamal M. Gamage, Wei Lun Ng, Wan Rong Sia, Randy Foo, Ning Yuan Shen, Wharton O. Y. Chan, Shiwei Chen, Vivian Chih-Wei Chen, Beng Lee Lim, Chee Wah Tan, Lin-Fa Wang   +11 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Emerging infectious diseases - staying vigilant tracking emerging infectious diseases

Staying vigilant tracking emerging infectious diseases: CDC\u2019s activities to protect Americans from emerging health threats are a foundation of many critical NCEZID infectious disease programs.

core  

Performance of the Trioplex real-time RT-PCR assay for detection of Zika, dengue, and chikungunya viruses

Nature Communications, 2018
The Trioplex real-time RT-PCR assay was developed for detection of Zika virus infections in areas with dengue and chikungunya transmission. Here, Santiago et al.
Gilberto A. Santiago, Jesús Vázquez, Sean Courtney, Katia Y. Matías, Lauren E. Andersen, Candimar Colón, Angela E. Butler, Rebecca Roulo, John Bowzard, Julie M. Villanueva, Jorge L. Muñoz-Jordan   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

National Center for Emerging and Zoonotic Infectious Diseases protecting health at home and abroad [PDF]

CDC\u2019s National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) protects people in the United States and around the globe from emerging (new) and zoonotic (spread between people and animals) infectious diseases.

core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Human health implications of emerging diseases and the current situation in India's vaccine industry. [PDF]

Sci One Health, 2023
Behera JK, Mishra P, Jena AK, Behera B, Bhattacharya M.   +4 more
europepmc   +1 more source