Results 81 to 90 of about 594,306 (305)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus

Communications Biology
Bats as the only flying mammals incur a high metabolic cost during extended powered flight, which results in febrile-like temperatures without injury. Herein, we investigate the in vivo heat shock response (HSR) in the cave nectar bat Eonycteris spelaea.
Leon J. W. Tang, Akshamal M. Gamage, Wei Lun Ng, Wan Rong Sia, Randy Foo, Ning Yuan Shen, Wharton O. Y. Chan, Shiwei Chen, Vivian Chih-Wei Chen, Beng Lee Lim, Chee Wah Tan, Lin-Fa Wang   +11 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Clinical performance of real-time nanopore metagenomic sequencing for rapid identification of bacterial pathogens in cerebrospinal fluid: a pilot study

Scientific Reports
This study aimed to evaluate the usefulness of amplicon-based real-time metagenomic sequencing applied to cerebrospinal fluid (CSF) for identifying the causative agents of bacterial meningitis. We conducted a 16S rRNA amplicon sequencing using a nanopore-
Yoon Hyun Sung, Yong Kuk Ju, Hak Jun Lee, Seung Min Park, Jin Woong Suh, Jeong Yeon Kim, Jang Wook Sohn, Young Kyung Yoon   +7 more
doaj   +1 more source

First detection and genetic characterization of canine Kobuvirus in domestic dogs in Thailand

BMC Veterinary Research, 2019
Background Canine Kobuvirus (CaKoV) has been detected both in healthy and diarrheic dogs and in asymptomatic wild carnivores. In this study, we conducted a survey of CaKoV at small animal hospitals in Bangkok and vicinity of Thailand during September ...
Kamonpan Charoenkul, Taveesak Janetanakit, Supassama Chaiyawong, Napawan Bunpapong, Supanat Boonyapisitsopa, Ratanaporn Tangwangvivat, Alongkorn Amonsin   +6 more
doaj   +1 more source

Bone marrow-derived mesenchymal stem cells attenuate pulmonary inflammation and lung damage caused by highly pathogenic avian influenza A/H5N1 virus in BALB/c mice

BMC Infectious Diseases, 2020
Background The highly pathogenic avian influenza A/H5N1 virus is one of the causative agents of acute lung injury (ALI) with high mortality rate. Studies on therapeutic administration of bone marrow-derived mesenchymal stem cells (MSCs) in ALI caused by ...
Resti Yudhawati, Muhammad Amin, Fedik A. Rantam, Rima R. Prasetya, Jezzy R. Dewantari, Aldise M. Nastri, Emmanuel D. Poetranto, Laksmi Wulandari, Maria I. Lusida, Soetjipto Koesnowidagdo, Gatot Soegiarto, Yohko K. Shimizu, Yasuko Mori, Kazufumi Shimizu   +13 more
doaj   +1 more source

Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentre randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection [PDF]

, 2005
Poster Presentations: Emerging / Infectious Diseases: abstract no.
Lee, KH, Hung, IFN, To, KKW, Lin, CK, Chan, KH, Liu, SH, Lau, CCY, Lai, KY, Liu, R, Chow, FL, Lee, CK, Law, KI, Ngai, CW, Chan, WM, Chan, K, Yan, WW, Yuen, KY   +16 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Emerging infectious diseases [PDF]

Emerging Infectious Diseases is providing access to these abstracts on behalf of the ICEID 2012 program committee (www.iceid.org), which performed peer review.
International Conference on Emerging Infectious Diseases (2012 : Atlanta, GA)
core   +3 more sources

Adaptive evolution during the establishment of European avian‐like H1N1 influenza A virus in swine

Evolutionary Applications, 2018
An H1N1 subtype influenza A virus with all eight gene segments derived from wild birds (including mallards), ducks and chickens, caused severe disease outbreaks in swine populations in Europe beginning in 1979 and successfully adapted to form the ...
Udayan Joseph, Dhanasekaran Vijaykrishna, Gavin J.D. Smith, Yvonne C.F. Su   +3 more
doaj   +1 more source