Results 61 to 70 of about 594,203 (304)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine

npj Vaccines, 2022
Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic.
Jenny G. Low, Ruklanthi de Alwis, Shiwei Chen, Shirin Kalimuddin, Yan Shan Leong, Tania Ken Lin Mah, Natalene Yuen, Hwee Cheng Tan, Summer L. Zhang, Jean X. Y. Sim, Yvonne F. Z. Chan, Ayesa Syenina, Jia Xin Yee, Eugenia Z. Ong, Rose Sekulovich, Brian B. Sullivan, Kelly Lindert, Sean M. Sullivan, Pad Chivukula, Steven G. Hughes, Eng Eong Ooi   +20 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Detection of Ehrlichia ruminantium infection in cattle in Cameroon

BMC Research Notes, 2018
Objectives Ehrlichia ruminantium infection (heartwater) is a major constraint that impacts negatively on the cattle industry development in sub-Saharan Africa and so far, little is known of the presence of heartwater in cattle in Cameroon.
Seraphine N. Esemu, Roland N. Ndip, Lucy M. Ndip   +2 more
doaj   +1 more source

Occurrence of tuberculosis among people exposed to cattle in Bangladesh

Veterinary Medicine and Science, 2023
Background Tuberculosis (TB) has been an important public health concern in Bangladesh. The most common cause of human TB is Mycobacterium tuberculosis, while bovine TB is caused by Mycobacterium bovis.
Shamim Sarkar, Najmul Haider, Ariful Islam, Muhammad Belal Hossain, Kamal Hossain, Mohammad Khaja Mafij Uddin, Arfatur Rahman, Syed Sayeem Uddin Ahmed, Sayera Banu, Zeaur Rahim, James D. Heffelfinger, Nord Zeidner   +11 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection

mSphere, 2019
Dengue is caused by infection with any one of four dengue viruses (DENV); the risk of severe disease appears to be enhanced by the cross-reactive or subneutralizing levels of antibody from a prior DENV infection.
Candice Y. Y. Chan, John Zhong Heng Low, Esther Shuyi Gan, Eugenia Ziying Ong, Summer Li-Xin Zhang, Hwee Cheng Tan, Xiaoran Chai, Sujoy Ghosh, Eng Eong Ooi, Kuan Rong Chan   +9 more
doaj   +1 more source

Molecular detection and whole genome characterization of Canine Parainfluenza type 5 in Thailand

Scientific Reports, 2021
Parainfluenza virus type 5 (PIV-5) causes respiratory infection in several animal species and humans. Canine parainfluenza virus type 5 (CPIV-5) causes respiratory disease in domestic dogs worldwide.
Kamonpan Charoenkul, Chanakarn Nasamran, Taveesak Janetanakit, Supassama Chaiyawong, Napawan Bunpapong, Supanat Boonyapisitsopa, Ratanaporn Tangwangvivat, Alongkorn Amonsin   +7 more
doaj   +1 more source

Infectious Diseases Institute [PDF]

, 2017
IMPACT. 1: Provide infectious diseases communications and resources for the community, key stakeholders, and policy makers.OSU PARTNERS: College of Arts and Sciences; College of Dentistry; College of Education and Human Ecology; College of Engineering ...
Oglesbee, Mike
core  

Immune responses of wild birds to emerging infectious diseases [PDF]

, 2015
Over the past several decades, outbreaks of emerging infectious diseases (EIDs) in wild birds have attracted worldwide media attention, either because of their extreme virulence or because of alarming spillovers into agricultural animals or humans.
Bonneaud, Camille, Staley, M.
core   +1 more source