Results 211 to 220 of about 13,374 (270)

A binding site for the antibiotic GE81112 in the ribosomal mRNA channel. [PDF]

mBio
Schedlbauer A, Han X, van Bakel W, Kaminishi T, Ochoa-Lizarralde B, Iturrioz I, Çapuni R, Parry R, Zegarra R, Gil-Carton D, López-Alonso JP, Barragan Sanz K, Brandi L, Gualerzi CO, Fucini P, Connell SR.   +15 more
europepmc   +1 more source

Lipid Droplets are active translation depots that respond to infection

Jha RM, Menon D, Nahak A, Kumar A, Choudhary V, Gandotra S.   +5 more
europepmc   +1 more source

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Emetine exerts anticancer effects in U2OS human osteosarcoma cells via activation of p38 and inhibition of ERK, JNK, and β‐catenin signaling pathways

Journal of biochemical and molecular toxicology, 2021
Osteosarcoma (OS) is a primary bone neoplasm that is highly malignant. As advances in chemotherapy for the treatment of OS have stagnated, discovery of new reagents is required.
Juhyeon Son, Sang Yeol Lee
semanticscholar   +1 more source

Emetine‐Loaded Black Phosphorus Hydrogel Sensitizes Tumor to Photothermal Therapy through Inhibition of Stress Granule Formation

Advanced Functional Materials, 2020
During photothermal therapy (PTT), hyperthermia up to 50 °C is required for efficient induction of tumor cell death. Additional increases in temperature can lead to severe damage to adjacent tissues.
Jianlei Xie, Taojian Fan, Ji Hyeon Kim, Yunjie Xu, Yingwei Wang, Weiyuan Liang, Lijun Qiao, Zongze Wu, Quan Liu, Weibin Hu, Na Yin, Ling Yang, Liping Liu, Jong Seung Kim, Han Zhang   +14 more
semanticscholar   +1 more source

Antineoplastic Agents. 607. Emetine Auristatins.

Journal of Natural Products, 2020
The remarkable biological activity of the dolastatin 10 structural modifications quinstatins and isoquinstatins prompted further investigation into drug hybrids containing biologically active isoquinoline moieties.
G. Pettit, N. Melody, J. Chapuis
semanticscholar   +1 more source

Natural Products Homoharringtonine and Emetine Alkaloids for SARSCoV-2 Treatment Options.

Current pharmaceutical design, 2020
BACKGROUND Viruses are known as the major causative agents for infectious diseases globally. The coronaviruses are one of the serious pathogens to cause serious diseases in humans.
S. S. Sohrab, M. Suhail, M. Kamal, E. Azhar   +3 more
semanticscholar   +1 more source

Season and shading affect emetine and cephalin production in Carapichea ipecacuanha plants

Plant Biosystems, 2020
Ipecacuanha [Carapichea ipecacuanha) (Brot) L. Andersson] has a high commercial value due to the presence of emetine and cephalin in its roots, which can be enhanced by different levels of light intensity.
Caíssa Machado Perucci Pereira dos Santos, Cristina Moll Hüther, J. Borella, Fernanda Naiara Santos Ribeiro, Glauce Christian Alves Duarte, Luiza Ferreira de Carvalho, E. de Oliveira, Osmar Alves Lameira, Camila Ferreira de Pinho, Thelma de Barros Machado, Carlos Rodrigues Pereira   +10 more
semanticscholar   +1 more source

Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension: Novel Effects of an Old Drug.

Arteriosclerosis, Thrombosis and Vascular Biology, 2019
OBJECTIVE Excessive proliferation and apoptosis resistance are special characteristics of pulmonary artery smooth muscle cells (PASMCs) in pulmonary arterial hypertension (PAH). However, the drugs in clinical use for PAH target vascular dilatation, which
M. Siddique, K. Satoh, Ryo Kurosawa, Nobuhiro Kikuchi, Md. Elias-Al-Mamun, J. Omura, T. Satoh, Masamichi Nogi, S. Sunamura, S. Miyata, H. Ueda, H. Tokuyama, H. Shimokawa   +12 more
semanticscholar   +1 more source

The constitution of emetine

Experientia, 1949
NachSpâth undPailer gibt es drei mogliche Strukturformeln (I–III) fur Emetin. Von diesen wurde (II) durch Ozonolyse des Hoffmannschen Degradationsproduktes (IV) ausgeschlossen. Auf der Grundlage von (I) wird eine neue Strukturformel des Cyanintyps fur die Rubremetiniumsalze vorgeschlagen (V).
A R, BATTERSBY, H T, OPENSHAW, H C S, WOOD   +2 more
openaire   +2 more sources