Results 11 to 20 of about 14,492 (168)
Longitudinal Monocyte Subset Dynamics as Biomarker in Adult Histiocytosis: Association With Mutational Status, Kinase Inhibitor Exposure and Relapse Risk. [PDF]
Hematol OncolHematological Oncology, Volume 44, Issue 5, September 2026.Razanamahery J, Raymond C, Papo M, Pegoraro F, Guy J, Aho LS, Emile JF, Samson M, Audia S, Haroche J, Bonnotte B. +10 moreeuropepmc +2 more sourcesCapacity building in medicines development and regulation in Africa—Overview on recent progress
British Journal of Clinical Pharmacology, EarlyView.Aims
Despite advances in health research and digital innovation, many African countries continue to face substantial resource constraints, fragmented capacity‐building efforts and a shortage of skilled professionals in medicines development and regulatory science.Tirhani Maluleke, Emile Malan, Michael Reid, Patrick Bouic, Haylene Nell, Goonaseelan Pillai, Catriona Waitt, Bernd Rosenkranz +7 morewiley +1 more sourceRedefining Fluoroquinolone Antibiotics: Design and Synthesis of Degradable Fluoroquinolones to Reduce Environmental Persistence. [PDF]
ChemSusChemRedesign and development of an efficient, robust synthesis platform for environmentally improved fluoroquinolones. A significant challenge associated with antibiotics, and active pharmaceutical ingredients in general, is their intentional design for high stability, which promotes environmental persistence and contributes to the development of ...Raeymackers N, Mol E, Yenokyan M, Suk M, Kümmerer K, Heugebaert TSA, Stevens CV. +6 moreeuropepmc +2 more sourcesLegacy effects of locally extinct flagship species on protected areas
Frontiers in Ecology and the Environment, EarlyView.Protected areas (PAs) are often established to conserve flagship megafauna so as to mobilize political support and secure sustained conservation investment, with the expectation that flagship‐centered governance will also protect habitat. Despite such efforts, flagship species can experience extirpation, raising a fundamental question: do conservation ...Rachakonda Sreekar, James EM Watson, Jiajia Liu, Aakash Lamba, Hoong Chen Teo, Jun Ying Lim, Yiwen Zeng +6 morewiley +1 more sourceSingle‐stage revision for chronic fistulized infected total knee arthroplasty achieves infection‐free survival comparable to non‐fistulized cases
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose
The presence of a sinus tract in chronic periprosthetic joint infection (PJI) has traditionally been considered a contraindication to single‐stage total knee arthroplasty (TKA) revision. However, an increasing number of surgeons are now performing single‐stage revisions in this context, despite limited comparative data.Arthur Barbaret, Joseph Jacquet, Patrice Wong, David Zhu, Florian Collignon, Thomas Oberle, Louis Lajoinie, Clement Ferri, Kamel Rouizi, Gregoire Vaz, Andrea Fernandez, Sibylle Bevilacqua, Olivier Roche +12 morewiley +1 more sourceSex Differences in Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross‐Sectional Analysis
Movement Disorders Clinical Practice, EarlyView.Abstract Background
Female sex is an independent fall risk factor in Parkinson's disease (PD), yet sex‐specific fall patterns remain unclear. Objectives
To compare sex‐specific fall risk and outcomes across PD, prodromal alpha‐synucleinopathy (PAS), and healthy controls (HC); estimate fall frequency across PD progression; and assess how sex modifies ...Joaquin A. Vizcarra, Kat Hefter, David‐Erick Lafontant, Michael Tran Duong, Ashkan Ertefaie, Brian Litt, Dani S. Bassett, Andrew Siderowf, The Parkinson's Progression Markers Initiative, Kenneth Marek, Caroline Tanner, Tanya Simuni, Andrew Siderowf, Douglas Galasko, Lana Chahine, Christopher Coffey, Kalpana Merchant, Kathleen Poston, Roseanne Dobkin, Tatiana Foroud, Brit Mollenhauer, Dan Weintraub, Ethan Brown, Karl Kieburtz, Mark Frasier, Todd Sherer, Sohini Chowdhury, Roy Alcalay, Aleksandar Videnovic, Duygu Tosun‐Turgut, Werner Poewe, Susan Bressman, Jan Hammer, Raymond James, Ekemini Riley, John Seibyl, Leslie Shaw, David Standaert, Sneha Mantri, Nabila Dahodwala, Michael Schwarzschild, Connie Marras, Hubert Fernandez, Ira Shoulson, Helen Rowbotham, Paola Casalin, Claudia Trenkwalder, Todd Sherer, Sohini Chowdhury, Mark Frasier, Jamie Eberling, Katie Kopil, Alyssa O’Grady, Maggie McGuire Kuhl, Leslie Kirsch, Tawny Willson, Emily Flagg, Tanya Simuni, Bridget McMahon, Craig Stanley, Kim Fabrizio, Dixie Ecklund, Trevis Huff, Tatiana Foroud, Laura Heathers, Christopher Hobbick, Gena Antonopoulos, John Seibyl, Kathleen Poston, Christopher Coffey, Chelsea Caspell‐Garcia, Michael Brumm, Bioinformatics Core, Arthur Toga, Karen Crawford, Tatiana Foroud, Jan Hamer, Brit Mollenhauer, Doug Galasko, Kalpana Merchant, Andrew Singleton, Tatiana Foroud, Thomas Montine, Caroline Tanner, Carlie Tanner, Ethan Brown, Lana Chahine, Roseann Dobkin, Monica Korell, Charles Adler, Roy Alcalay, Amy Amara, Paolo Barone, Bastiaan Bloem, Kathrin Brockmann, Norbert Brüggemann, Lana Chahine, Kelvin Chou, Nabila Dahodwala, Alberto Espay, Stewart Factor, Hubert Fernandez, Michelle Fullard, Douglas Galasko, Penelope Hogarth, Shu‐Ching Hu, Michele Hu, Stuart Isaacson, Christine Klein, Rejko Krueger, Mark Lew, Zoltan Mari, Connie Marras, Maria Jose Martí, Nikolaus McFarland, Tiago Mestre, Brit Mollenhauer, Emile Moukheiber, Alastair Noyce, Wolfgang Oertel, Njideka Okubadejo, Sarah O’Shea, Rajesh Pahwa, Nicola Pavese, Werner Poewe, Ron Postuma, Giulietta Riboldi, Lauren Ruffrage, Javier Ruiz Martinez, David Russell, Marie H. Saint‐Hilaire, Neil Santos, Wesley Schlett, Ruth Schneider, Holly Shill, David Shprecher, Tanya Simuni, David Standaert, Leonidas Stefanis, Yen Tai, Caroline Tanner, Arjun Tarakad, Eduardo Tolosa, Aleksandar Videnovic, Susan Ainscough, Courtney Blair, Erica Botting, Isabella Chung, Kelly Clark, Ioana Croitoru, Kelly DeLano, Iris Egner, Fahrial Esha, May Eshel, Frank Ferrari, Victoria Kate Foster, Alicia Garrido, Madita. Grümmer, Bethzaida Herrera, Ella Hilt, Chloe Huntzinger, Raymond James, Farah Kausar, Christos Koros, Yara Krasowski, Dustin Le, Ying Liu, Taina M. Marques, Helen Mejia Santana, Sherri Mosovsky, Jennifer Mule, Philip Ng, Lauren O’Brien, Abiola Ogunleye, Oluwadamilola Ojo, Obi Onyinanya, Lisbeth Pennente, Romina Perrotti, Michael Pileggi, Ashwini Ramachandran, Deborah Raymond, Jamil Razzaque, Shawna Reddie, Kori Ribb, Kyle Rizer, Janelle Rodriguez, Stephanie Roman, Clarissa Sanchez, Cristina Simonet, Anisha Singh, Elisabeth Sittig, Angela Stovall, Bobbie Stubbeman, Alejandra Valenzuela, Catherine Wandell, Diana Willeke, Karen Williams, Dilinuer Wubuli +197 morewiley +1 more sourceIntegrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective
To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby +127 morewiley +1 more sourceFacing Truths About Population Management
Zoo Biology, EarlyView.Populations of wildlife, and domestic animals have large sinks for surplus animals. By contrast, zoos don't. Humans in industrialized societies are socialized with companion animals, i.e. surplus (i.e., typically denied reproduction) originating from unseen breeding cores.Marcus Clauss, Andrew J. Abraham, Jörg Beckmann, Mads F. Bertelsen, Laurie Bingaman Lackey, Anita Burkevica, Miguel Casares, Severin Dressen, Adam Eyres, Karin Federer, Richard Gibson, Sven Hammer, Therese Hard, Stefan Hoby, Felix V. Husemann, Jacques Kaandorp, Christine M. Kaandorp‐Huber, Bjarne Klausen, Tobias Knauf‐Witzens, José Kok, Maya S. Kummrow, Sébastien Laurent, Arne Lawrenz, Sabrina Linn, Imke Lueders, Pascal Marty, Dennis W. H. Müller, Baptiste Mulot, Rolf‐Arne Ølberg, Theo B. Pagel, Zjef Pereboom, Jan Pluháček, Emile F. Prins, Sandra Reichler‐Danielowski, Douglas Richardson, Marco Roller, Lara Scherer, Tim F. Schikora, Chrispijn M. Schilp, Mark Snowball, Julia Stagegaard, Hanspeter W. Steinmetz, Job B. G. Stumpel, Cyriel Ververs, Chris Walzer, Christian Wenker, Guido Westhoff, Brian Zimmerman, João Pedro Meireles +48 morewiley +1 more sourceContrasting associations between parental coordination and breeding success in albatrosses across differing environmental contexts
Journal of Animal Ecology, EarlyView.Our study demonstrates that the benefits of parental coordination in albatrosses are context‐dependent rather than universal. Coordinated parental care enhanced reproductive success in stable environments, but had little effect in variable environments, where individual flexibility may be more valuable.Natasha Gillies, Richard A. Phillips, Henri Weimerskirch, Jonathan R. Potts, Denis Réale, Alastair J. Wilson, Frédéric Angelier, Christophe Barbraud, Ashley Bennison, Karine Delord, Prescillia Lemesle, Samuel Peroteau, Andrew G. Wood, José C. Xavier, Samantha C. Patrick +14 morewiley +1 more source
