Results 61 to 70 of about 44,379 (345)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

New Symbiotic Stars from LAMOST DR10 Spectra and Multiband Photometry

The Astrophysical Journal
The Symbiotic star (SySt) is a long-period interacting binary system, typically consisting of a white dwarf (WD) and a red giant surrounded by a nebula. These systems are natural astrophysical laboratories for investigating binary star evolution. In this
Jing Chen, Liang Wang, Yin-Bi Li, Xiao-Xiao Ma, A-Li Luo, Zi-Chong Zhang, Ming-Yi Ding, Kai Zhang   +7 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Intensity Interferometry Observations of the Hα Envelope of γCas with MéO and a Portable Telescope

The Astronomical Journal, 2023
We report on observations of the extended environment of the bright Be star γ -Cas performed using intensity interferometry measurements within its H α emission line.
Nolan Matthews, Jean-Pierre Rivet, David Vernet, Mathilde Hugbart, Guillaume Labeyrie, Robin Kaiser, Julien Chabé, Clément Courde, Olivier Lai, Farrokh Vakili, Olivier Garde, William Guerin   +11 more
doaj   +1 more source

Dust formation and evolution in the ejecta of core-collapse supernovae [PDF]

, 2015
Observations of local supernovae over the past couple of decades have reported the presence of dust in the ejecta. The dust masses inferred from observations in mid-infrared and submillimeter wavelengths differ by a factor of 10^2 to 10^4 The composition
Sarangi, Arkaprabha
core   +1 more source

On the Formation of Balmer Emission Lines in the Model Envelopes of Be Stars [PDF]

Symposium - International Astronomical Union, 1994
We consider the formation of the Balmer emission lines and the decrement Hα/Hβ/Hγ, by solving the non-LTE problems in elementary regions of the envelope divided by equal line-of-sight velocities. These envelope-elements are characterized by different optical depths in the Balmer lines and by different dilution factors for the incident stellar radiation.
T. Kogure, S. Suzuki, M. Mon
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A search for radio emission from exoplanets around evolved stars [PDF]

, 2018
The majority of searches for radio emission from exoplanets have to date focused on short period planets, i.e., the so-called hot Jupiter type planets.
H. Olofsson, Sirothia, S., Ray, T. P., T. P. Ray, O Gorman, Eamon, Olofsson, H., Coughlan, C. P., Olofsson, H.,, Sirothia, S.,, Vlemmings, Wouter, Vlemmings, Wouter,, E. O’Gorman, O Gorman, Eamon,, Ray, T. P.,, Coughlan, C. P.,, S. Sirothia, C. P. Coughlan, Varenius, Eskil, Varenius, Eskil,, W. Vlemmings, E. Varenius   +20 more
core   +1 more source

Superfast line profiles variability in spectra of OBA stars

, 2021
We present new results of our Large Project for revealing the superfast line profile variations (sfLPVs) in spectra of bright OBA stars. The regular variations of the line profiles with periods ranging from a few hours to days in spectra of all massive ...
Valeev, A.F., Ikonnikova, N.P., Kholtygin, A.F., Moiseeva, A.V., Kostenkov, A.E., Burlak, M.A., Tsiopa, O.A., Yakunin, I.A., Ryspaeva, E.B., Kurdoyakova, M.S., Fabrika, S.N.   +10 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source