Results 91 to 100 of about 3,807,656 (336)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Addressing Low-Cost Methane Sensor Calibration Shortcomings with Machine Learning

Atmosphere
Quantifying methane emissions is essential for meeting near-term climate goals and is typically carried out using methane concentrations measured downwind of the source.
Elijah Kiplimo, Stuart N. Riddick, Mercy Mbua, Aashish Upreti, Abhinav Anand, Daniel J. Zimmerle   +5 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Application of PET/CT in Predicting and Evaluating the Therapeutic Response in Chemotherapy of Solid Tumor

Journal of Isotopes, 2017
Three aspects of the application of PET/CT in solid tumor chemotherapy were summarized, including the selection of evaluation criteria, the proper time of using PET/CT in the evaluation and the parameters of PET/CT in evaluating the response of ...
positron emission tomography solid tumor chemotherapy predicton of therapeutic response
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Overlooked crisis: cold temperature amplifies particle number emissions from gasoline vehicles

Environment International
This study systematically investigates particle number (PN) emissions from light-duty gasoline vehicles through chassis dynamometer (60 emission test runs spanning −7 °C to 40 °C) combined with mechanistic analysis, revealing a severely underestimated ...
Xihui Tong, Haiguang Zhao, Yongshuai Qu, Jie Yao, Jia Ke, Junchao Zhao, Tianyu Zhai, Xin Li, Xinping Yang, Yunjing Wang, Hang Yin, Yan Ding   +11 more
doaj   +1 more source

Photoluminescence from In0.5Ga0.5As/GaP quantum dots coupled to photonic crystal cavities

, 2012
We demonstrate room temperature visible wavelength photoluminescence from In0.5Ga0.5As quantum dots embedded in a GaP membrane. Time-resolved above band photoluminescence measurements of quantum dot emission show a biexpontential decay with lifetimes of ~
Buckley, Sonia, Lee, Minjoo Larry, Rivoire, Kelley, Song, Yuncheng, Vuckovic, Jelena   +4 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Extragalactic jets: the high energy view

, 2004
I review the current knowledge of high-energy emission from extragalctic jets. First I discuss gamma-ray emission from blazars, which provides us numerous precious information on the innermost portions of the relativistic jets. I describe the constraints
Tavecchio, Fabrizio
core   +2 more sources

Damage Analysis of Composite CFRP Tubes Using Acoustic Emission Monitoring and Pattern Recognition Approach [PDF]

, 2021
Michal Šofer, Jakub Cienciala, Martin Fusek, Pavel Pavlíček, Richard A Moravec   +4 more
openalex   +1 more source