Results 71 to 80 of about 3,249,465 (306)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
VLBI Imaging of Water Maser Emission from the Nuclear Torus of NGC 1068 [PDF]
, 1996 We have made the first VLBI synthesis images of the H2O maser emission associated with the central engine of the Seyfert galaxy NGC 1068. Emission extends about +/-300 km/s from the systemic velocity. Images with submilliarcsecond angular resolution show
Antonucci R. R. J. +7 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Computational Fluid Dynamics-Based Modeling of Methane Flows Around Oil and Gas Equipment
AtmosphereRecent studies estimate that emissions from oil and gas production facilities contribute between 20 and 50% of the total methane (CH4) emitted in the US; therefore, quantifying and reducing these emissions are crucial for achieving climate goals. Methane
Abhinav Anand +7 more
doaj +1 more source
Survey of available technologies for zero carbon and energy balance houses [PDF]
E3S Web of ConferencesThe decarbonization of industry is important to minimize the negative aspects of climate changes. One of the industrial direction is the civil engineering industry, including construction and building flats, houses, and commercial property.
Mičko Kristián, Sol’aková Tatiana
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
European Transport Research ReviewIn the present study road safety impact analysis for certain advanced driver assistance systems (ADAS) was conducted. Based on a literature review, expert interviews and current adaptations in legislation, the most promising nine ADAS were selected.
Michael Aleksa +5 more
doaj +1 more source
A correlation between the IRAS infrared cirrus at 60 or 100 microns and neutral atomic hydrogen in the outer galaxy [PDF]
A linear correlation was found between the infrared cirrus at 100 or 60 microns and neutral atomic hydrogen near the galactic plane. Infrared Astronomy Satellite (IRAS) Sky Brightness images were compared to the 0.5 deg resolution Weaver-Williams HI ...
hermal dust emission., Terebey, Susan
core +1 more source