Results 61 to 70 of about 1,979,826 (299)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Is Emission Trading Beneficial? [PDF]

We develop a two-country (North and South), two-good, general equilibrium model of international trade in goods and explore the effects of domestic and international emission trading under free trade in goods.
Yomogida, Morihiro, Ishikawa, Jota, Kiyono, Kazuharu   +2 more
core   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Impact analysis of Advanced Driver Assistance Systems (ADAS) regarding road safety – computing reduction potentials

European Transport Research Review
In the present study road safety impact analysis for certain advanced driver assistance systems (ADAS) was conducted. Based on a literature review, expert interviews and current adaptations in legislation, the most promising nine ADAS were selected.
Michael Aleksa, Andrea Schaub, Isabela Erdelean, Stephan Wittmann, Aggelos Soteropoulos, Alexander Fürdös   +5 more
doaj   +1 more source

Computational Fluid Dynamics-Based Modeling of Methane Flows Around Oil and Gas Equipment

Atmosphere
Recent studies estimate that emissions from oil and gas production facilities contribute between 20 and 50% of the total methane (CH4) emitted in the US; therefore, quantifying and reducing these emissions are crucial for achieving climate goals. Methane
Abhinav Anand, Stuart Riddick, Kira B. Shonkwiler, Aashish Upreti, Michael Moy, Elijah Kiplimo, Mercy Mbua, Daniel J. Zimmerle   +7 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Synergistic benefits of agrivoltaics in enhancing microclimate, solar panel efficiency, and physiological and biochemical attributes of Hibiscus rosa-sinensis

BMC Plant Biology
The growing need for renewable energy coupled with land-use competition for food production, advocates the value of agrivoltaics (AV) as a double remedy to the conundrum of energy and agriculture.
M. Nasir Khan, Hani Albalawi, Hazem M. El-Hageen, Zahid H. Siddiqui   +3 more
doaj   +1 more source

Estimating Total Methane Emissions from the Denver-Julesburg Basin Using Bottom-Up Approaches

Gases
Methane is a powerful greenhouse gas with a 25 times higher 100-year warming potential than carbon dioxide and is a target for mitigation to achieve climate goals. To control and curb methane emissions, estimates are required from the sources and sectors
Stuart N. Riddick, Mercy Mbua, Abhinav Anand, Elijah Kiplimo, Arthur Santos, Aashish Upreti, Daniel J. Zimmerle   +6 more
doaj   +1 more source