Results 41 to 50 of about 2,685,096 (249)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Dual-pulse laser induced breakdown spectroscopy in the vacuum ultraviolet with ambient gas: spectroscopic analysis and optimization of limit of detection of carbon and sulfur in steel [PDF]

, 2012
Laser Induced Breakdown Spectroscopy (LIBS) in the vacuum ultraviolet (VUV) spectral region was applied to standard steel samples in dual-pulse excitation mode with an ambient gas. Two lasers were employed in collinear geometry, one as an ablation laser (
Jiang, Xi
core   +2 more sources

Environmental and food security implications of livestock abortions and calf mortality: a case study in Kenya and Tanzania

Frontiers in Sustainable Food Systems
This study investigates the environmental and food security implications of livestock abortions and calf mortality in Tanzanian dairy systems and Kenyan beef systems by utilizing data from previously published studies.
Endale B. Gurmu, Endale B. Gurmu, Barend Bronsvoort, Barend Bronsvoort, Elizabeth A. J. Cook, Elizabeth A. J. Cook, Felix Lankester, Felix Lankester, Şeyda Özkan, Peri K. Rosenstein, George Semango, Nick Wheelhouse, Nick Wheelhouse, Andreas Wilkes, Claudia Arndt   +14 more
doaj   +1 more source

The impact of the digital economy on carbon emission intensity: Evidence from China

Frontiers in Environmental Science, 2023
Evaluating the impact of the digital economy on carbon emission intensity has great significance in promoting sustainable development. Based on the panel data of 30 provinces in China from 2013 to 2019, the level of the digital economy is estimated by ...
Xiaochun Zhao, Mei Jiang, Ying Zhou
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Emissions Targets and the Real Business Cycle: Intensity Targets versus Caps or Taxes [PDF]

For reducing greenhouse gas emissions, intensity targets are attracting interest as a flexible mechanism that would better allow for economic growth than emissions caps.
Fischer, Carolyn, Springborn, Michael R.
core   +2 more sources

ICT, Energy Intensity, and CO₂ Emission Nexus

Energies, 2022
The relationship between information and communication technology investment (ICT), environmental impacts, and economic growth has received increasing attention in the last 20 years.
Melike E. Bildirici, Rui Alexandre Castanho, Fazıl Kayıkçı, Sema Yılmaz Genç   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

CO2 emission in India: trends and management at sectoral, sub-regional and plant levels

Carbon Management, 2017
The paper estimates the Indian carbon dioxide (CO2) emissions over the last two decades at sectoral and sub-regional levels to identify hotspots of CO2 emissions, providing possible insights for focused carbon mitigation efforts pan-India.
Amit Garg, P.R. Shukla, Bhushan Kankal, Diptiranjan Mahapatra   +3 more
doaj   +1 more source