Results 101 to 110 of about 3,929,924 (389)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The effect of climate and climate change on ammonia emissions in Europe [PDF]
, 2013 We present here a dynamical method for modelling temporal and geographical variations in ammonia emissions in regional-scale chemistry transport models (CTMs) and chemistry climate models (CCMs).
Geels, C., Skjøth, C.
core +2 more sources
Influence of tribology on global energy consumption, costs and emissions
, 2017 Calculations of the impact of friction and wear on energy consumption, economic expenditure, and CO2 emissions are presented on a global scale. This impact study covers the four main energy consuming sectors: transportation, manufacturing, power ...
K. Holmberg, A. Erdemir
semanticscholar +1 more source
Geoscientific Model Development, 2018 . We present a suite of nine scenarios of future emissions trajectories of anthropogenic sources, a key deliverable of the ScenarioMIP experiment within CMIP6.
M. Gidden +22 more
semanticscholar +1 more source
The European Union Emissions Trading System reduced CO2 emissions despite low prices
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance International carbon markets are an appealing and increasingly popular tool to regulate carbon emissions. They put a price on carbon emissions and make pollution less attractive for regulated firms.
P. Bayer, M. Aklin
semanticscholar +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
Environmental Protection and Natural Resources, 2018 The aim of this article is to discuss the following judgement of the European Court of Justice in case C-460/15 Schaefer Kalk GmbH & Co. KG v Bundesrepublik Deutschland concerning the EU Emissions Trading Scheme (EU ETS):
Siwior Przemysław, Bukowska Joanna
doaj +1 more source
Nitrous oxide emissions from soils: how well do we understand the processes and their controls?
Philosophical Transactions of the Royal Society B: Biological Sciences, 2013 Although it is well established that soils are the dominating source for atmospheric nitrous oxide (N2O), we are still struggling to fully understand the complexity of the underlying microbial production and consumption processes and the links to biotic (
K. Butterbach‐Bahl +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source