Results 101 to 110 of about 4,465,271 (408)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Conspicuously absent: shipping emissions in climate change policy [PDF]
, 2017 This repository item contains a single issue of Issues in Brief, a series of policy briefs that began publishing in 2008 by the Boston University Frederick S.
Cowing, Rebecca
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
On-Board Sensor-Based NO x Emissions from Heavy-Duty Diesel Vehicles [PDF]
, 2019 Real-world nitrogen oxides (NOx) emissions were estimated using on-board sensor readings from 72 heavy-duty diesel vehicles (HDDVs) equipped with a Selective Catalytic Reduction (SCR) system in California.
Boriboonsomsin, Kanok +9 more
core +2 more sources
Influence of tribology on global energy consumption, costs and emissions
, 2017 Calculations of the impact of friction and wear on energy consumption, economic expenditure, and CO2 emissions are presented on a global scale. This impact study covers the four main energy consuming sectors: transportation, manufacturing, power ...
K. Holmberg, A. Erdemir
semanticscholar +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Carbon Footprint Assessment and Mitigation Options of Dairy under Chinese Conditions [PDF]
, 2019 With the rapid human population growth and economic development, demand for animal products continues to increase and livestock production rapidly expands.
Dong, Hongmin
core
The effect of climate and climate change on ammonia emissions in Europe [PDF]
, 2013 We present here a dynamical method for modelling temporal and geographical variations in ammonia emissions in regional-scale chemistry transport models (CTMs) and chemistry climate models (CCMs).
Geels, C., Skjøth, C.
core +2 more sources
Pulsar optical emission as amplified synchrotron emission [PDF]
Monthly Notices of the Royal Astronomical Society, 1981 Pulsed optical emission has been observed from the Crab and Vela pulsars (Manchester and Taylor 1977). The pulse profile of the Crab pulsar has a main pulse and a strong interpulse separated by about 40% of the pulsar period; the peak of the main pulse is just resolved at 20 μs resolution; the spectrum is peaked at about 1014.8 Hz; the pulse profile is
openaire +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source