Results 61 to 70 of about 806,958 (301)

ALMA Observations of the Protostar L1527 IRS: Probing Details of the Disk and the Envelope Structures

, 2017
We have newly observed the Class 0/I protostar L1527 IRS using the Atacama Large Millimeter/submillimeter Array (ALMA) during its Cycle 1 in 220 GHz dust continuum and C18O (J=2-1) line emissions with a ~2 times higher angular resolution (~0.5") and ~4 ...
Aikawa, Yuri, Aso, Yusuke, Machida, Masahiro N., Ohashi, Nagayoshi, Saigo, Kazuya, Saito, Masao, Takakuwa, Shigehisa, Tomida, Kengo, Tomisaka, Kohji, Yen, Hsi-Wei   +9 more
core   +1 more source

In situ N2O emissions are not mitigated by hippuric and benzoic acids under denitrifying conditions [PDF]

, 2014
This research was financially supported under the National Development Plan, through the Research Stimulus Fund, administered by the Department of Agriculture, Food and the Marine (Grant numbers RSF10/RD/SC/716 and 11S138).peer-reviewedRuminant urine ...
Forrestal, Patrick J., Krol, Dominika, Lanigan, Gary, Richards, Karl G.   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

IPA: Class 0 Protostars Viewed in CO Emission Using JWST

The Astrophysical Journal
Abstract We investigate the bright CO fundamental emission in the central regions of five protostars in their primary mass assembly phase using new observations from JWST’s Near-Infrared Spectrograph and Mid-Infrared Instrument. CO line emission images and fluxes are extracted for a forest of ∼150 rovibrational transitions from two ...
Adam E. Rubinstein, Neal J. Evans, Himanshu Tyagi, Mayank Narang, Pooneh Nazari, Robert Gutermuth, Samuel Federman, P. Manoj, Joel D. Green, Dan M. Watson, S. Thomas Megeath, Will R. M. Rocha, Nashanty G. C. Brunken, Katerina Slavicinska, Ewine F. van Dishoeck, Henrik Beuther, Tyler L. Bourke, Alessio Caratti o Garatti, Lee Hartmann, Pamela Klaassen, Hendrik Linz, Leslie W. Looney, James Muzerolle, Thomas Stanke, John J. Tobin, Scott J. Wolk, Yao-Lun Yang   +26 more
openaire   +6 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Greenhouse Gas Mitigation and Yield Response to Biochar-Microbial Amendment in Saline-Alkali Soil

Shuitu Baochi Xuebao
[Objective] To investigate the effects of combined application of biochar and microbial fertilizer on greenhouse gas emissions and sunflower yield in saline-alkali soil under plastic film mulching and drip irrigation.
QIN Jianjie, YANG Wei, ZHANG Ruxin, ZHANG Yudi, REN Enliang, JI Wentao, QU Zhongyi   +6 more
doaj   +1 more source

Straw utilization for biofuel production: A consequential assessment of greenhouse gas emissions from bioethanol and biomethane provision with a focus on the time dependency of emissions

GCB Bioenergy, 2020
The shift from straw incorporation to biofuel production entails emissions from production, changes in soil organic carbon (SOC) and through the provision of (co‐)products and entailed displacement effects.
Benedikt Buchspies, Martin Kaltschmitt, Martin Junginger   +2 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Constraining light dependency in modeled emissions through comparison to observed biogenic volatile organic compound (BVOC) concentrations in a southeastern US forest [PDF]

Atmospheric Chemistry and Physics
Climate change will bring about changes in meteorological and ecological factors that are currently used in global-scale models to calculate biogenic emissions.
N. S. Panji, D. F. McGlynn, L. E. R. Barry, T. M. Scanlon, M. T. Lerdau, S. E. Pusede, G. Isaacman-VanWertz   +6 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source