Results 51 to 60 of about 12,583 (231)

Multi‐Omics Insights Into Anthraquinone Biosynthesis in Rheum tanguticum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rheum tanguticum is renowned for its medicinal properties, including purgative, anti‐inflammatory and hepatoprotective effects, primarily attributed to anthraquinones (AQs). However, the molecular mechanisms of AQs biosynthesis have largely been hindered by insufficient genomic resources and functional genomics investigations.
Shuo Zhao, Yuan Zong, Tao Wang, Jianan Li, Zengrong Ye, Famei Zhang, Guoying Zhou   +6 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Emodin coupled with high LET neutron beam—a novel approach to treat on glioblastoma [PDF]

, 2022
Jeong‐Yub Kim, Chan‐Woong Jung, Won Seok Lee, Hyeon-Jeong Jeong, Myung‐Jin Park, Won Il Jang, Eun Ho Kim   +6 more
openalex   +1 more source

Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)

European Journal of Histochemistry
Chronic kidney disease (CKD) is a leading public health issue associated with high morbidity worldwide. However, there are only a few effective therapeutic strategies for CKD.
Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan   +8 more
doaj   +1 more source

Emodin promotes apoptosis of human endometrial cancer through regulating the MAPK and PI3K/ AKT pathways

Open Life Sciences, 2019
Emodin, a major component of rhubarb, has anti-tumor effects in a variety of cancers, influencing multiple steps of tumor development through modulating several signaling pathways.
Jiang Jun, Zhou Nanyang, Ying Pian, Zhang Ting, Liang Ruojia, Jiang Xuelu   +5 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Ion Chemistry in Dielectric Barrier Discharge Ionization: Recent Advances in Direct Gas Phase Analyses

Mass Spectrometry Reviews, Volume 45, Issue 2, Page 193-217, March/April 2026.
ABSTRACT Dielectric barrier discharge ionization (DBDI) sources, employing low‐temperature plasma, have emerged as sensitive and efficient ionization tools with various atmospheric pressure ionization processes. In this review, we summarize a historical overview of the development of DBDI, highlighting key principles of gas‐phase ion chemistry and the ...
Kseniya Dryahina, Miroslav Polášek, Juraj Jašík, Kristýna Sovová, Patrik Španěl   +4 more
wiley   +1 more source

Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin

International Journal of Nanomedicine, 2012
Tiechuang Wang1, Xiaodong Yin2, Yaping Lu1, Weiguang Shan1, Subin Xiong11College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, People's Republic of China; 2Baxter International Inc, Shanghai, People's Republic ...
Wang T, Yin X, Lu Y, Shan W, Xiong S
doaj  

Aloe-emodin glycosides of senna leaf

Journal of Pharmacy and Pharmacology, 1966
Abstract A new glucoside has been isolated from senna leaf (Cassia senna L.) and shown to be identical with the aloe-emodin-8-mono-β-D-glucoside recently isolated from Rheum palmatum. This new quinone glucoside is insoluble in water and is present in only small quantities and therefore unlikely to contribute much to the activity of the ...
J W, Fairbairn, A B, Shrestha
openaire   +2 more sources

Adh1‐Programmed SNF1 Phosphogradients Decrypt Morphogenesis in Candida albicans: Chemical Interrogation Unveils Hyphal Transition Thresholds

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
Based on the ADH1 knockout strain, HAQ was identified through forward/reverse genetic screening of 114 natural products and analysis of protein ligand and protein–protein interactions. With the help of HAQ, a new mechanism for regulating the phosphorylation level of Adh1–SNF1 has been revealed, in which HAQ binds to Adh1 to release dephosphorylation ...
Ziqi Wang, Ziran Wang, Qi Zhang, Yuanyuan Song, Haoying Zhang, Qin Xu, Jianmin Liao, Yuanyuan Lu   +7 more
wiley   +1 more source