Results 81 to 90 of about 9,423 (183)

Emodin enhances osteogenesis and inhibits adipogenesis.

BMC complementary and alternative medicine, 2014
It has been suggested that the formation of osteoblasts in bone marrow is closely associated with adipogenesis, and the balance between osteogenesis and adipogenesis differentiation of MSCs (mesenchymal stem cells) is disrupted in osteoporosis. In order to improve the treatment of osteoporosis, available agents with roles of regulating the balance is ...
Yang, Feng, Yuan, Pu-wei, Hao, Yang-Quan, Lu, Zheng-Mao   +3 more
openaire   +2 more sources

Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis

Clinical and Experimental Hypertension
Background Emodin is a traditional medicine that has been shown to exert anti-inflammatory and anti-oxidative effects. Previous research has indicated that emodin can alleviate myocardial remodeling and inhibit myocardial hypertrophy and fibrosis ...
Wei Huang, Peiting Zhou, Xinyun Zou, Yunchuan Liu, Longfu Zhou, Yaolei Zhang   +5 more
doaj   +1 more source

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes

Drug Design, Development and Therapy, 2019
Xiao-yuan Zheng1, Shi-ming Yang2, Rong Zhang1, Su-min Wang2, Guo-bing Li1, Shi-wen Zhou1 1Department of Pharmacy, Xinqiao Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of Gastroenterology, Xinqiao Hospital ...
Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S   +5 more
doaj  

Emodin induced hepatic steatosis in BALb/c mice by modulating the gut microbiota composition and fatty acid metabolism

Frontiers in Pharmacology
IntroductionThe aim of this study is to examine the physiological effects of emodin on intestinal microorganisms and the liver in the BALb/c mice.Method and ResultsFollowing an 8-week administration of emodin at doses of 25, 50, and 100 mg/kg/day ...
Xinhua Xia, Xinhua Xia, Xueling He, Jinzhou Huang, Jinzhou Huang, Xuyang Hou, Xuyang Hou, Chen Lin, Chen Lin, Yaxiong Liu, Mei Liu   +10 more
doaj   +1 more source

Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation

Journal of Inflammation
Background Intestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin on I/R injury.
Yinyin Liu, Tuo Ji, Haixing Jiang, Meng Chen, Wanli Liu, Zongze Zhang, Xianghu He   +6 more
doaj   +1 more source

Aloe-Emodin and Emodin's Role in Premalignant Lesions of the Oral Cavity Cancers and other Organs

Abstract Oral squamous cell carcinoma (OSCC) is one of the commonest cancers globally. Prevalence of the disease is high in the third world countries of South-east Asia, specifically tied to inherent abuse of tobacco and areca nuts. The disease manifests as oral potentially malignant disorders, such as OED, OSMF, leukoplakias, etc., that provides ...
Abhijit G. Banerjee, Gargi Roy Goswami, Tapas Mukherjee   +2 more
openaire   +2 more sources

In-vivo Antioxidant Effects of Emodin on Ischemia-Reperfusion Injury of Rat's Skeletal Muscle. [PDF]

Drug Des Devel Ther
Yiğit D, Oktar GL, Demirtaş H, Özer A, Küçük A, Yığman Z, Tekin E, Arslan M.   +7 more
europepmc   +1 more source

Comprehensive Review on the Toxicity of Five Main AQ Constituents from Rhubarb: Mechanisms, Challenges and Future Perspectives. [PDF]

Drug Des Devel Ther
Yu L, Jiang Y, Li P, Wang J, Tang P, Zhao Y.   +5 more
europepmc   +1 more source

Emodin Exerts Dual Hepatoprotective/Hepatotoxic Effects Dependent on Metabolic Microenvironment via Gut-Liver Axis Crosstalk: A Multi-Omics Study in MAFLD and Normal Mice. [PDF]

Int J Mol Sci
Mao R, Guo Y, Zhang H, Wang R, Cheng Y, Li H, Wang Y, Wang Y.   +7 more
europepmc   +1 more source

Novel Aloe-Emodin Derivatives as Potential Anticancer Agents: Synthesis, Characterization and Cytotoxic Activity. [PDF]

Molecules
Semerel J, Zheng S, Hu H, Fang Y, John N, Fardim P, Dehaen W.   +6 more
europepmc   +1 more source