Results 121 to 130 of about 2,394,864 (253)

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

The daily association between positive affect and psychotic experiences in individuals along the early stages of the psychosis continuum

Frontiers in Psychiatry
IntroductionPsychosis often develops gradually along a continuum of severity. Little is known about the role of protective factors such as positive affect (PA) in the development of psychotic experiences (PEs).
Sara van der Tuin, Lorna Staines, Larisa Morosan, Esdras Raposo-Almeida, Esdras Raposo-Almeida, David van den Berg, David van den Berg, Sanne H. Booij, Sanne H. Booij, Albertine J. Oldehinkel, Johanna T. W. Wigman   +10 more
doaj   +1 more source

Fear of emotion in adolescents: the Modified Affective Control Scale for Adolescents-Revised [PDF]

, 2010
Difficulties in emotion regulation, in the form of fear of emotion, have been studied in adults but have received scant attention within the adolescent population.
Koh, Delphine
core  

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Predictors, daily correlates, and effects on future functioning of resilience in patients with Major Depressive Disorder (MDD)

Journal of Affective Disorders Reports
Background: Psychological resilience, as a potential protective factor, has been linked to enhanced wellbeing and reduced psychopathology. This study investigated the predictors, associations, and prospective effects of resilience to daily hassles in ...
Vera E. Heininga, Albertine J. Oldehinkel   +1 more
doaj   +1 more source

The Influence of Parent Mental Health on Parenting and Child Emotion Regulation

, 2018
This study examined 56 families with preschool aged children. Mothers and fathers completed self-reports of depression, anxiety, and parenting behaviors (CES-D, STAI, and CCNES).
Mather, Abby
core  

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Emotion regulation in minority and majority families in Türkiye: A qualitative investigation [PDF]

openThis qualitative study explored emotion regulation strategies among children and adolescents (aged between 10–18 years) from ethnic and religious minority and majority groups in Türkiye, their mothers’ emotion socialization practices, and the ...
OZSEKER, EKIN
core  

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source