Results 131 to 140 of about 2,616,516 (303)

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Predictors, daily correlates, and effects on future functioning of resilience in patients with Major Depressive Disorder (MDD)

Journal of Affective Disorders Reports
Background: Psychological resilience, as a potential protective factor, has been linked to enhanced wellbeing and reduced psychopathology. This study investigated the predictors, associations, and prospective effects of resilience to daily hassles in ...
Vera E. Heininga, Albertine J. Oldehinkel   +1 more
doaj   +1 more source

PRESCHOOL TEACHERS' EMOTION REGULATION

Preschool students are three times more likely to be expelled than those students in kindergarten to 12th grade (Gilliam, 2005). A student who experienced being expelled in preschool is at a higher risk for future expulsion, dropping out of high school ...
Davis, Sara L.
core  

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

The affective roots of resource heterogeneity: How founders' emotion regulation helps create social resources in startups [PDF]

Where do firms' heterogeneous resources come from? Our qualitative, inductive study of nascent firms over seven years revealed that founders' differential use of emotion regula-tion behaviors can explain differential creation of social resources at the ...
Huy, Quy, Zott, Christoph
core  

Sub‐Second Ratiometric Fluorescence Imaging of Histamine Dynamics in Living Cells via a Supramolecular Probe

Advanced Science, EarlyView.
A tailored tripartite supramolecular ratiometric probe, engineered by modulating the fluorogenic guest's cationic locus, enables ultrafast histamine monitoring in living cells. Utilizing a competitive displacement mechanism, this system achieves a sub‐second response time with high selectivity.
Chenming Chan, Yujie Han, Yu‐Fei Song, Chunlei Jiang, Qi‐Wei Zhang   +4 more
wiley   +1 more source

Miss, I got mad today! The Anger Diary, a tool to promote emotion regulation [PDF]

, 2011
Effective management of emotions has strong implications in the development of adaptive behaviours during childhood and adolescence. The purpose of this study was to examine the use of a new method of emotion regulation named the 'aRRabbiadiaro' (Anger ...
Valeria Cavioni, Maria Assunta Zanetti, Cavioni, Valeria, Roberta Renati, Renati, Roberta, Zanetti, Maria Assunta   +5 more
core   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

When alarms are ignored: clinical reflections on ignorance culture in eating disorder care

BJPsych Bulletin
In his analysis of ‘ignorance culture’ in eating disorder services, Downs describes how repeated alarms raised by patients, carers and clinicians are routinely ignored, deflected or reframed as individual pathology.
Anita Federici
doaj   +1 more source