Results 121 to 130 of about 3,365,275 (312)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Eccomi pronto : implementation of a Socio-Emotional Development curriculum in a South Korean elementary school [PDF]

, 2015
‘Eccomi Pronto’ (EP), an elementary school socio-emotional learning curriculum that was originally developed and evaluated in Italy was translated in Korean and implemented and evaluated in 4th grade classrooms of a primary school in South Korea ...
Mortari, Luigina, Jessica Bertolani, Luigina Mortari, Jung H. Hyun, Carey, John, Jihee Lee, Kim, Donghyun, John Carey, Hyun, Jung H., Hyun Jung, Lee, Jihee, Donghyun Kim, Bertolani, Jessica   +12 more
core   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Emotional and Cognitive Self-Regulation

RUDN Journal of Psychology and Pedagogics, 2013
A brief outline of four studies that investigated interrelations of cognitive and emotional regulation in collaboration between Departments of Psychology of the University of Cincinnati and Kazakh National University is presented in this article. The aim
G Matthews, A M Kustubayeva, A Tolegenova, A Kamzanova, M Zholdassova   +4 more
doaj  

In to the feeling: doctoral students’ academic emotional experiences and regulation

Frontiers in Psychology
IntroductionThe process of doctoral students engaging in academic research involves a series of positive and negative academic-related emotional experiences, to cope with the change in emotional states, the use of emotional regulation strategies is ...
Yilong Ji, Qunfeng Gui, Gaoyu Chen, Yong Cui, Siyuan Chen   +4 more
doaj   +1 more source

Teachers’ emotional intelligence : the impact of training [PDF]

, 2016
A growing number of studies have suggested that teachers' personal competencies, and more specifically Emotional Intelligence (EI), are particularly important for teacher effectiveness.
Leshem, Shosh, Dolev, Nina, Nina Dolev, Shosh Leshem Abstract   +3 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Unable to Describe My Feelings and Emotions Without an Addiction: The Interdependency Between Alexithymia and Addictions

Frontiers in Psychiatry, 2020
Laura Orsolini, Laura Orsolini
doaj   +1 more source

Regulating emotions and learning motivation in higher education students [PDF]

, 2020
This study has a two-fold objective: First, to adapt and validate the Emotions and Motivation Self-Regulation Questionnaire (EMSR-Q) with university students in Colombia, and secondly, to verify whether the relationship model between emotional and ...
Alonso-Tapia, Jesús, Abello, Diana M., Panadero, Ernesto   +2 more
core