Results 141 to 150 of about 761,403 (304)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

TCF7L2 DEFICIENCY IN THE THALAMUS LEADS TO ALTERATIONS IN BEHAVIORAL PROFILE AND BRAIN ENERGY METABOLISM

IBRO Neuroscience Reports, 2023
Suelen Baggio, Andrzej Nagalski, Kamil Koziński, Łukasz Szewczyk, Marcin Lipiec, Ben Hur Mussulini, Ksenia Meiza, Anna Goncerzewicz, Ludwika Szczepańska, Ewelina Knapska, Agnieszka Chacinska, Marta Wiśniewska   +11 more
doaj   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Lived experiences of migrant men witnessing and surviving sexual violence in European transit spaces

Globalization and Health
Background Despite increased scholarly attention to sexual violence, victimization among migrant men and boys remains under researched. This study aims to explore 1) migrant men’s views on and understandings of sexual victimization, 2) their own ...
Leni Linthout, Ilse Derluyn, Caroline Desombre, Massil Benbouriche, Ines Keygnaert   +4 more
doaj   +1 more source

A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment

Advanced Science, EarlyView.
MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu, Huixuan Xu, Li Lin, Fei Wang, Yaodong Ding, Shuangqiao Liao, Xingyu Chen, Jichen Wen, Hongqiang Zhao, Jing Hao, Weixiang Zhao, Gong Zhang, Shiguang Shan, Yong Zeng, Hu Han, Minxian Wang   +15 more
wiley   +1 more source

EMOTIONS THAT INFLUENCE PURCHASE DECISIONS AND THEIR ELECTRONIC PROCESSING [PDF]

Recent studies have shown that most of our purchasing choices and decisions are theresult of a careful analysis of the advantages and disadvantages and of affective and emotionalaspects.
Domenico Consoli
core  

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Emotions and their relation to Health

, 2017
We constantly debate the relevance of emotional intelligence in our daily lives. My thesis highlights the components and physiology of emotions, emotional self-regulation, its role in the 'dis-eases' we feel and also in the world of Paediatrics and ...
Adeosun, Olubukola Rita
core  

Single‐Pulse Femtosecond Laser 3D Multi‐Foci Light‐Field Engineering via Multi‐Layer Noise Threshold Filtering

Advanced Science, EarlyView.
This study presents a single‐pulse femtosecond laser strategy for three‐dimensional multi‐foci light‐field shaping and high‐throughput micro/nano manufacturing. The multi‐layer noise threshold filtering algorithm improves focal quality, while the multi‐layer over‐sampling algorithm increases focal density.
Shouyu Wu, Ruiyang Wang, Lan Jiang, Mengyao Tian, Yongjiu Yuan, Junrui Wu, Liang Zhao, Ruochen Zhang, Ziqian Ning, Xin Li   +9 more
wiley   +1 more source