Results 71 to 80 of about 231,498 (381)

Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers

Inflammation and Regeneration
Background Tobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of insulin-like growth factor 2 (IGF2) in response to lung injury by tobacco carcinogens, 4-(methylnitrosamino)-1-(3 ...
Hye-Jin Boo, Hye-Young Min, Heung-Bin Lim, Euni Lee, Ho-Young Lee   +4 more
doaj   +1 more source

Polarized Helium to Image the Lung [PDF]

, 2005
The main findings of the european PHIL project (Polarised Helium to Image the Lung) are reported. State of the art optical pumping techniques for polarising ^3He gas are described. MRI methodological improvements allow dynamical ventilation images with a
Leduc, Michèle, Nacher, Pierre-Jean
core   +4 more sources

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression

Nature Communications
Tobacco smoking (TS) is implicated in lung cancer (LC) progression through the development of metabolic syndrome. However, direct evidence linking metabolic syndrome to TS-mediated LC progression remains to be established. Our findings demonstrate that 4-
Hyun-Ji Jang, Hye-Young Min, Yun Pyo Kang, Hye-Jin Boo, Jisung Kim, Jee Hwan Ahn, Seung Ho Oh, Jin Hwa Jung, Choon-Sik Park, Jong-Sook Park, Seog-Young Kim, Ho-Young Lee   +11 more
doaj   +1 more source

PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma

BMC Pulmonary Medicine, 2019
Background Emphysema and chronic obstructive pulmonary disease (COPD) are well known independent risk factors for lung cancer. However, the developmental mechanisms between emphysema/COPD and lung cancer remain unknown.
Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Satoru Shimizu, Noriyuki Shibata, Mitsuko Kondo, Kiyoshi Takeyama, Etsuko Tagaya   +7 more
doaj   +1 more source

The association of chest computed tomography-defined visual emphysema and prognosis in patients with nonsmall cell lung cancer

ERJ Open Research, 2023
Background Although computed tomography (CT)-defined emphysema is considered a predictor of lung cancer risk, it is not fully clear whether CT-defined emphysema is associated with the prognosis of lung cancer. We aimed to assess the clinical impact of CT-
Yixiao Zhang, Jiawen Yi, Dan Sun, Yanping Su, Yingting Zuo, Min Zhu, Shu Zhang, Kewu Huang, Xiaojuan Guo, Yuhui Zhang   +9 more
doaj   +1 more source

Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development [PDF]

, 2018
Cigarette smoke (CS) exposure is a major risk factor for the development of emphysema, a common disease characterized by loss of cells comprising the lung parenchyma.
Fisher, Amanda J., Justice, Matthew J., Lamb, Isaac, Petrache, Irina, Saliba, Jacob, Schweitzer, Kelly S., Sears, Catherine R., Wicker, Jessica, Zhou, Huaxin   +8 more
core   +1 more source

Dr. Hans Kohn and the political takeover of the Berlin Medical Society by the National Socialist regime in 1933

The Anatomical Record, EarlyView.
Abstract To solidify their power over society, totalitarian regimes will usually eliminate any dissent, any perceived threats early on. These threats include not only political enemies but also educated and independent segments of society, such as professional associations.
Michael Hortsch
wiley   +1 more source

Effect and Mechanism of Running on Mouse Emphysema Model Induced by Cigarette Extract

康复学报, 2022
ObjectiveTo observe the effect of running on mouse emphysema model induced by cigarette extract, and to explore its mechanism based on signal transducer and activator of transcription 3 (STAT3).MethodsA total of 40 male C57BL/6 mice were randomly divided
LI Yongrong, XIE Haibin, LI hong, SUN Jie   +3 more
doaj  

Basophils trigger emphysema development in a murine model of COPD through IL-4–mediated generation of MMP-12–producing macrophages

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Chronic obstructive pulmonary disease has generally been considered a non-Th2-type lung disease, in contrast to allergic asthma. We identified unexpected roles for basophils, Th2 cytokine IL-4, and interstitial macrophages in triggering ...
S. Shibata, K. Miyake, T. Tateishi, S. Yoshikawa, Y. Yamanishi, Y. Miyazaki, N. Inase, H. Karasuyama   +7 more
semanticscholar   +1 more source