Results 71 to 80 of about 213,364 (422)

TUXEDO: a phase I/II trial of cetuximab with chemoradiotherapy in muscle‐invasive bladder cancer

BJU International, Volume 131, Issue 1, Page 63-72, January 2023., 2023
Objective To assess the feasibility and preliminary efficacy of adding cetuximab to standard chemoradiotherapy for muscle‐invasive bladder cancer. Patients and Methods TUXEDO was a prospective, single‐arm, open‐label, phase I/II trial conducted in six UK hospitals. Cetuximab was administered with an initial loading dose of 400 mg/m2 on Day 1 of Week −1,
Nicholas D. James, Wenyu Liu, Sarah Pirrie, Baljit Kaur, Carey Hendron, Daniel Ford, Anjali Zarkar, Richard Viney, Elizabeth Southgate, Amisha Desai, Syed A. Hussain, on behalf of the TUXEDO investigators, Jim Barber, Isabel Syndikus, Zafar Malik, Chinnamani Eswar, Stephen Mangar, Julian Money‐Kyrle, Anna Lydon, Johannes Van Der Voet, Nicholas James, Anjali Zarkar, Dan Ford   +22 more
wiley   +1 more source

Novel Subtypes of Pulmonary Emphysema Based on Spatially-Informed Lung Texture Learning [PDF]

arXiv, 2020
Pulmonary emphysema overlaps considerably with chronic obstructive pulmonary disease (COPD), and is traditionally subcategorized into three subtypes previously identified on autopsy. Unsupervised learning of emphysema subtypes on computed tomography (CT) opens the way to new definitions of emphysema subtypes and eliminates the need of thorough manual ...
arxiv  

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression [PDF]

, 2010
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of proteases and antiproteases ...
A Babusyte, A Kode, A Papi, A Sebastian, A Sydbom, AP Rogerio, AW Boots, C Kandaswami, C Tabak, CJ Vlahos, D Nowak, DC Newcomb, EH Walker, G Agullo, GA Finlay, GW Peet, HJ Park, HS Deshmukh, HS Deshmukh, I Rahman, IC Walda, IK Demedts, J Robak, JA Conquer, JC Chen, JD Hasday, JH Vernooy, JW Hwang, K Ito, K Minamoto, K Ohnishi, KF Chung, KK Meja, L Biasutto, L Larsson, L Segura-Valdez, M Comalada, M Harwood, M Ichinose, M Kasielski, M Suzuki, MK Hwang, MM Mu, N Louhelainen, O Michel, P Maestrelli, P Santus, PC Hollman, PF Mercer, PJ Jagielo, R Mahadeva, S Nanua, S Rajendrasozhan, S Shishodia, SK Biswas, SP Davies, SV Culpitt, T Shinohara, T Zheng, U Sajjan, W MacNee, Y Kaneko, Y Nakamaru, Y-T Huang   +63 more
core   +6 more sources

Optimized Pt Loaded Cerium Tungstate Electrochemical Sensor for Rapid Response and Recovery NO2 Detection

Advanced Sensor Research, EarlyView.
Pt/Ce2(WO4)3, synthesized via simple calcination and hydrothermal methods, serves as a promising electrochemical gas sensor for detecting nitrogen dioxide (NO2). This study investigates the structural characteristics of the sensor. The sensor with 0.5 wt.% Pt loading exhibits the optimal sensing performance, demonstrating high sensitivity and ...
Jiaxin Li, Xichao Mo, Chonghui Zhu, Minghui Yang   +3 more
wiley   +1 more source

Value of metalloproteinases in predicting COPD in heavy urban smokers

Respiratory Research, 2020
Background Emphysema in asymptomatic heavy smokers can be detected during CT-scan screening for lung cancer. Metalloproteinases (MMPs) have been found to play a role in the pathogenesis of chronic obstructive pulmonary disease and to possibly serve as ...
Jun-Chieh J. Tsay, Yingjie Hu, Judith D. Goldberg, Bin Wang, Soumya Vijayalekshmy, Ting-An Yie, Katrina Bantis, Daniel H. Sterman, William N. Rom   +8 more
doaj   +1 more source

Broad subcutaneous emphysema with airway obstruction during robot‐assisted partial nephrectomy: A case report and literature review

IJU Case Reports, 2023
Introduction Subcutaneous emphysema is a relatively common complication in laparoscopic surgery. However, airway obstruction secondary to subcutaneous emphysema is rare.
Akihiro Ono, Masaki Nakamura, Tomoe Hayashi, Ibuki Tsuru, Taro Izumi, Masashi Kusakabe, Kazunari Nakao, Masanori Kashiwagi, Haruki Kume, Yoshiyuki Shiga   +9 more
doaj   +1 more source

Inter-vendor harmonization of Computed Tomography (CT) reconstruction kernels using unpaired image translation [PDF]

arXiv, 2023
The reconstruction kernel in computed tomography (CT) generation determines the texture of the image. Consistency in reconstruction kernels is important as the underlying CT texture can impact measurements during quantitative image analysis. Harmonization (i.e., kernel conversion) minimizes differences in measurements due to inconsistent reconstruction
arxiv  

Comorbid Conditions in Idiopathic Pulmonary Fibrosis: Recognition and Management. [PDF]

, 2017
Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial pneumonia of unknown etiology, primarily affects older adults and leads to a progressive decline in lung function and quality of life.
Collard, Harold R, Oldham, Justin M
core   +2 more sources

ADAR1‐HNRNPL‐Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
ADAR1‐HNRNPL interaction‐repressed circCANX recruits P53 mRNA and UPF1 to assemble a complex in nuclear. This complex promotes P53 mRNA degradation through the NMD pathway, and finally reduces autophagy and stress granules formation to further regulate inflammation.
Ting‐Ting Chen, Yuan‐Yuan Wei, Jia‐Ying Kang, Da‐Wei Zhang, Jing‐Jing Ye, Xi‐Shi Sun, Mei Hong, Wen‐Ting Zhang, Hui‐Mei Wu, Zhen‐Xing Ding, Guang‐He Fei   +10 more
wiley   +1 more source

Pulmonary Emphysema Regional Distribution and Extent Assessed by Chest Computed Tomography Is Associated With Pulmonary Function Impairment in Patients With COPD

Frontiers in Medicine, 2021
Objective: This study aimed to evaluate how emphysema extent and its regional distribution quantified by chest CT are associated with clinical and functional severity in patients with chronic obstructive pulmonary disease (COPD).Methods/Design: Patients ...
Plácido Gomes, Hélder Novais e Bastos, Hélder Novais e Bastos, Hélder Novais e Bastos, Hélder Novais e Bastos, André Carvalho, André Carvalho, André Lobo, Alan Guimarães, Rosana Souza Rodrigues, Rosana Souza Rodrigues, Walter Araujo Zin, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho   +15 more
doaj   +1 more source