Results 71 to 80 of about 218,651 (379)

Emphysema presence, severity, and distribution has little impact on the clinical presentation of a cohort of patients with mild to moderate COPD [PDF]

, 2011
Phenotypic characterization of patients with COPD may have potential prognostic and therapeutic implications. Available information on the relationship between emphysema and the clinical presentation in patients with COPD is limited
Alcaide, A.B. (Ana Belén), Bastarrika, G. (Gorka), Campo, A. (Arantza), Montes, U. (Usúa), Saiz-Mendiguren, R. (R.), Seijo, L. (Luis), Torres, J.P. (Juan P.) de, Zagaceta, J. (Jorge), Zulueta, J. (Javier)   +8 more
core   +1 more source

Electrical Impedance Tomography in Medical Applications: Brain and Lung

iLABMED, EarlyView.
The clinical focus of EIT technology lies in lung function monitoring and neurological diseases, while also exploring new scenarios such as abdominal hemorrhage detection. Technological breakthroughs include the development of wearable devices and the optimization of hardware architecture.
Sibo Lian, Bo Sun, Zihan Zhao, Juan Jiao, Fenghuan Wang   +4 more
wiley   +1 more source

PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma

BMC Pulmonary Medicine, 2019
Background Emphysema and chronic obstructive pulmonary disease (COPD) are well known independent risk factors for lung cancer. However, the developmental mechanisms between emphysema/COPD and lung cancer remain unknown.
Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Satoru Shimizu, Noriyuki Shibata, Mitsuko Kondo, Kiyoshi Takeyama, Etsuko Tagaya   +7 more
doaj   +1 more source

Lung Volume Reduction Coil Treatment vs Usual Care in Patients With Severe Emphysema: The REVOLENS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE Therapeutic options for severe emphysema are limited. Lung volume reduction using nitinol coils is a bronchoscopic intervention inducing regional parenchymal volume reduction and restoring lung recoil.
G. Deslée, H. Mal, H. Dutau, A. Bourdin, J. Vergnon, C. Pison, R. Kessler, V. Jounieaux, L. Thiberville, S. Leroy, A. Marceau, S. Laroumagne, J. Mallet, Sylvain Dukic, C. Barbe, Julie Bulsei, D. Jolly, I. Durand-zaleski, C. Marquette   +18 more
semanticscholar   +1 more source

Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression

Nature Communications
Tobacco smoking (TS) is implicated in lung cancer (LC) progression through the development of metabolic syndrome. However, direct evidence linking metabolic syndrome to TS-mediated LC progression remains to be established. Our findings demonstrate that 4-
Hyun-Ji Jang, Hye-Young Min, Yun Pyo Kang, Hye-Jin Boo, Jisung Kim, Jee Hwan Ahn, Seung Ho Oh, Jin Hwa Jung, Choon-Sik Park, Jong-Sook Park, Seog-Young Kim, Ho-Young Lee   +11 more
doaj   +1 more source

Role of Dual-Specificity Phosphatase 1 in Glucocorticoid-Driven Anti-inflammatory Responses

Frontiers in Immunology, 2019
Glucocorticoids (GCs) potently inhibit pro-inflammatory responses and are widely used for the treatment of inflammatory diseases, such as allergies, autoimmune disorders, and asthma. Dual-specificity phosphatase 1 (DUSP1), also known as mitogen-activated
Jessica Hoppstädter, Alaina J. Ammit, Alaina J. Ammit   +2 more
doaj   +1 more source

The association of chest computed tomography-defined visual emphysema and prognosis in patients with nonsmall cell lung cancer

ERJ Open Research, 2023
Background Although computed tomography (CT)-defined emphysema is considered a predictor of lung cancer risk, it is not fully clear whether CT-defined emphysema is associated with the prognosis of lung cancer. We aimed to assess the clinical impact of CT-
Yixiao Zhang, Jiawen Yi, Dan Sun, Yanping Su, Yingting Zuo, Min Zhu, Shu Zhang, Kewu Huang, Xiaojuan Guo, Yuhui Zhang   +9 more
doaj   +1 more source

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem, and current therapy for COPD is poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Adenuga, Adenuga, Adenuga, Adenuga, Algood, Allison, Andersson, Andre, Anest, Arunachalam, Bannister, Barnes, Beeh, Bertolotti, Bessac, Biswal, Blake, Borchers, Borchers, Borchers, Bowie, Bracke, Caito, Caito, Calabrese, Capelli, Carrero, Carrozza, Celedon, Chen, Chen, Chen, Chen, Chen, Cheung, Cho, Christman, Church, Combadiere, Combadiere, Cosio, Costa, Csiszar, Cullinan, Cullinan, Dahl, De Boer, De Boer, de Boer, De Boer, de Ruijter, Decramer, Dekhuijzen, Dentener, Di Stefano, Dinarello, Donnelly, Duran, Edirisinghe, El Moussaoui, Facchinetti, Feghali-Bostwick, Ferrer, Foronjy, Franciosi, Furukawa, Galasinski, Ganguly, Gargalovic, Georgiou, Ghosh, Gongora, Goven, Gracie, Grumelli, Hardaker, Harding, Harju, Harju, Harrison, He, Hengstermann, Hogg, Hogg, Hongwei Yao, Hoshino, Hoshino, Hoshino, Hung, Hwang, Ichinose, Igishi, Iizuka, Imaoka, Imhof, Irfan Rahman, Ishii, Ito, Ito, Ito, Ito, Jorgensen, Juul, Kamei, Kang, Kang, Kasahara, Kassim, Kawahara, Keatings, Keatings, Kelsen, Kim, Kinnula, Kode, Kucukaycan, Lee, Lee, Lee, Leitges, Liu, Lukacs, Luo, Macnee, MacNee, Mahler, Mak, Malhotra, Mattagajasingh, McComb, Meja, Michaud, Michishita, Milne, Milne, Miotto, Mojtahedi, Moretti, Morrison, Motz, Murooka, Nakamaru, Nan, Netea, Niess, Ning, Nisoli, Nozik-Grayck, Ota, Ota, Pantano, Park, Pesci, Petersen, Petrache, Pinamonti, Porter, Potente, Potente, Rabe, Rahman, Rahman, Rahman, Rahman, Rajendrasozhan, Rajendrasozhan, Rangasamy, Rennard, Repine, Ryter, Rytila, Saetta, Saha, Saha, Sandford, Scherz-Shouval, Scherz-Shouval, Senftleben, Sengupta, Sethi, Sethi, Shapiro, Siedlinski, Simon, Singh, Siva, Sizemore, Soler, Sullivan, Sussan, Suzuki, Thatcher, Thomson, Tomaki, Traves, Trevisani, Tsoumakidou, Tuder, Turato, van der Pouw Kraan, van der Strate, van der Vlies, Van Gool, van Overveld, Vaziri, Vermeulen, Vlahos, Wang, Widdowson, Wright, Wright, Xiao, Yagi, Yamamoto, Yamato, Yang, Yang, Yang, Yang, Yang, Yang, Yao, Yao, Yao, Yao, Yin, Young, Zhang, Zhang, Zheng, Zochbauer-Muller   +230 more
core   +1 more source

Basophils trigger emphysema development in a murine model of COPD through IL-4–mediated generation of MMP-12–producing macrophages

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Chronic obstructive pulmonary disease has generally been considered a non-Th2-type lung disease, in contrast to allergic asthma. We identified unexpected roles for basophils, Th2 cytokine IL-4, and interstitial macrophages in triggering ...
S. Shibata, K. Miyake, T. Tateishi, S. Yoshikawa, Y. Yamanishi, Y. Miyazaki, N. Inase, H. Karasuyama   +7 more
semanticscholar   +1 more source

Clinical progress note: Pertussis

Journal of Hospital Medicine, EarlyView.
Abstract Pertussis, commonly known as whooping cough, is a vaccine‐preventable respiratory disease with rising incidence due to declining vaccination rates and waning immunity. The most severe disease course is seen in unvaccinated or incompletely vaccinated infants less than 2 months of age, accounting for the largest burden of hospitalization and ...
Samantha Hanna, Nicole Samies
wiley   +1 more source