Results 31 to 40 of about 4,856,660 (339)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Assessing temporary product-specific subsidies: a time series intervention analysis
Research in StatisticsWe propose an analytical forecasting framework to quantify the distortionary effects of product-specific subsidies. The novelty consists of a dual approach combining intervention analysis and a state-space modeling approach to construct and assess ...
David Leuwer +2 more
doaj +1 more source
Demand methods of price management: An empirical research [PDF]
, 2006 One factor which companies often take as a reference point for their pricing decisions is demand. This, however, is often done only partially, with priority being given to quantitative factors rather than qualitative factors.
Rosa Díaz, Isabel María +1 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Media and Communication, 2019 The intense use of digital media among children and adolescents raises concerns about online risks. In response, digital literacy frameworks for formal education usually include a set of protective skills.
Priscila Berger, Jens Wolling
doaj +1 more source
A clinical heritage of empirical research. In memory of Jeremy Safran [PDF]
, 2019 This is Part II of a special issue, Research in Psychotherapy: Psychopathology, Process and Outcome, dedicated in memory of our colleague Jeremy Safran (Part I was published in April 2019).
Gentile, Daniela, Lingiardi, Vittorio
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The empirical approach to research in property law [PDF]
, 2014 This article offers an account of the unique characteristics, challenges and benefits of empirical legal research. The authors explain that empirical legal research involves the collection and observation of data through a variety of research techniques,
Bright, Susan, Whitehouse, Lisa
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Integrating trait-based empirical and modeling research to improve ecological restoration [PDF]
, 2018 A global ecological restoration agenda has led to ambitious programs in environmental policy to mitigate declines in biodiversity and ecosystem services.
Fiedler, Sebastian +2 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source