Results 41 to 50 of about 29,976 (278)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The scientific method of Sir William Petty
Erasmus Journal for Philosophy and Economics, 2011 An understanding of the precise nature of the scientific method of Sir William Petty has proved elusive to historians of economic thought, in no small part because of a lack of Petty's own characterization of his scientific approach.
James H. Ullmer
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Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
DoisPontos, 2008 This article begins with an internal argument in the philosophy of Gilles Deleuze: every philosophy’s character might be evaluated by the immanence degree it accomplishes.
Hélio Rebello Cardoso Jr
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Treating of bodies medical and political
Erasmus Journal for Philosophy and Economics, 2016 Medicine was one of the chief empirical and philosophical sources for early modern political economy, helping to move analysis from moral to natural philosophy, and Mandeville was educated as a physician.
Harold J. Cook
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Aging and Cancer, EarlyView.This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
The Arbitrariness of Faith-Based Medical Exemptions
Religions, 2023 There are a variety of reasons for which one might claim an exemption from a public health mandate such as a required COVID-19 vaccine. Good-faith exemption requests—for medical, religious, or other reasons—are generally recognized as legitimate and ...
Aaron Quinn
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Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
An Empirical Analysis of Perceptual Judgments
The Baltic International Yearbook of Cognition, Logic and Communication, 2014 This paper is a defense of Reformed Empiricism, especially against those critics who take Reformed Empiricism to be a viable account of empirical rationality only if it avails itself of certain rationalist assumptions that are inconsistent with ...
Nicholas Ray
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