Results 61 to 70 of about 20,437 (299)

The scientific method of Sir William Petty

open access: yesErasmus Journal for Philosophy and Economics, 2011
An understanding of the precise nature of the scientific method of Sir William Petty has proved elusive to historians of economic thought, in no small part because of a lack of Petty's own characterization of his scientific approach.
James H. Ullmer
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Pengaruh penambahan media limbah jamur merang dalam pupuk organik cair terhadap konsentrasi kaslium [PDF]

open access: yes, 2020
Pupuk organic cair merupakan pupuk yang berupa larutan dari hasil pembusukan bahan-bahan organik. Kombinasi whey tahu dan limbah jamur merang dengan penambahan starter mikroorganisme lokal (MOL) dapat diolah menjadi pupuk organik cair mengandung makro ...
Hulyadi, Hulyadi   +2 more
core   +1 more source

An Empirical Analysis of Perceptual Judgments

open access: yesThe Baltic International Yearbook of Cognition, Logic and Communication, 2014
This paper is a defense of Reformed Empiricism, especially against those critics who take Reformed Empiricism to be a viable account of empirical rationality only if it avails itself of certain rationalist assumptions that are inconsistent with ...
Nicholas Ray
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

The Coherence of Empiricism [PDF]

open access: yes, 2002
Rationalists often argue that empiricism is incoherent and conclude, on that basis, that some knowledge is a priori. I contend that such arguments against empiricism cannot be parlayed into an argument in support of the a priori since rationalism is open
Casullo, Albert
core   +2 more sources

Does Neoclassical Econometrics Have a Scientific Foundation? A Critique Based on Hollis and Nell

open access: yesRevue Interventions Économiques, 2014
The 2008 global financial crisis has rekindled the debate over the scientific foundations of neo-Classical econometrics. Neo-Classical based econometrics interprets whatever it sees as individuals choosing with some degree of (perhaps bounded ...
Karim Errouaki
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Defusing Transcendental Empiricism: Deleuze, Hume, and Empiricism [PDF]

open access: yes, 2016
This dissertation addresses the problem of conflating the conditions of experience with the given of experience. The conditions of experience are by definition not contents of experience.
Kravet, Scott Leigh
core   +1 more source

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