Results 51 to 60 of about 20,437 (299)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Popper, Kuhn, Lakatos and Aim-Oriented Empiricism [PDF]

open access: yes, 2005
In this paper I argue that aim-oriented empiricism (AOE), a conception of natural science that I have defended at some length elsewhere, is a kind of synthesis of the views of Popper, Kuhn and Lakatos, but is also an improvement over the views of all ...
Maxwell, Nicholas, Maxwell, N
core  

Ceticismo de Hume através do Empirismo Transcendental de Deleuze: disjunção inclusiva e sujeito empírico

open access: yesDoisPontos, 2008
This article begins with an internal argument in the philosophy of Gilles Deleuze: every philosophy’s character might be evaluated by the immanence degree it accomplishes.
Hélio Rebello Cardoso Jr
doaj  

Ce qu’atteint l’expérience du vouloir : Hume, Locke, Malebranche

open access: yesAstérion, 2016
Starting from an excerpt of An Enquiry Concerning Human Understanding (section 7, part I), this article compares the conceptions that Hume, Locke and Malebranche uphold regarding the experience we have of the power of our will.
Sophie Bergont
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Do We Need a Scientific Revolution? [PDF]

open access: yes, 2008
Many see modern science as having serious defects, intellectual, social, moral. Few see this as having anything to do with the philosophy of science.
Maxwell, Nicholas, Maxwell, N
core   +1 more source

Treating of bodies medical and political

open access: yesErasmus Journal for Philosophy and Economics, 2016
Medicine was one of the chief empirical and philosophical sources for early modern political economy, helping to move analysis from moral to natural philosophy, and Mandeville was educated as a physician.
Harold J. Cook
doaj   +1 more source

Hermann Cohen and His Idea of the Logic of Pure Knowledge

open access: yesRUDN Journal of Philosophy, 2021
Hermann Cohen, as it is well known, criticised the Kantian notion of the thing-in-itself. And before him the Kantian thing-in-itself was criticised by Fichte and other German idealists.
Zinaida A. Sokuler
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Grounded Empiricism [PDF]

open access: yes
Empiricism has a long and venerable history. Aristotle, the Epicureans, Sextus Empiricus, Bacon, Locke, Hume, Mill, Mach and the Logical Empiricists, among others, represent a long line of historically influential empiricists who, one way or another ...
Votsis, Ioannis
core   +1 more source

Home - About - Disclaimer - Privacy