Results 51 to 60 of about 1,841,982 (314)

Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein

npj Imaging
In this work, the impact of physicochemical modifications on pharmacokinetics and in vivo targeting of a small molecule fibroblast activation protein inhibitor (FAPI) imaging ligand in a murine model of rheumatoid arthritis was evaluated.
Radhika Narain, Ian Nessler, Paul L. Richardson, Jamie E. Erickson, Yuzhen Wang, Jacqueline Ferri, Heather L. Knight, Shaughn H. Bryant, Lucy A. Phillips, Liang Zhang, Soumya Mitra   +10 more
doaj   +1 more source

Doxycycline as a potential partner of COVID-19 therapies

IDCases, 2020
Coronavirus disease 2019 (COVID-19) is a major public health challenge, and the current antiviral arsenal for treatment is limited, with questionable efficacy.
Alexandre E. Malek, Bruno P. Granwehr, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Terapi Refleksi Al-Fatihah (Al-Fatihah Reflection Therapy)

Psikologika: Jurnal Pemikiran dan Penelitian Psikologi, 2017
Al Fatihah reflection Therapy (ART) is a theistic psychotherapy that shares characteristics with Cognitive Behavior Therapy (CBT) from Beck. However, the conceptualization and intervention emphasis differs in some ways.
Saktiyono B. Purwoko
doaj   +1 more source

Employee Engagement and Employee Turnover

Indian Journal of Applied Research, 2011
In today's context, most of the Indian business organizations are facing a paradoxical problem so far as employment of their human resources is concerned. On one hand, they are facing the problem of overstaff- ing and are busy to pruning the surplus staff through voluntary retirement and other schemes.
Dr. C. SWARNALATHA Dr. C. SWARNALATHA, T. S. PRASANNA T. S. PRASANNA   +1 more
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evaluation of a pulsed xenon ultraviolet disinfection system to decrease bacterial contamination in operating rooms

BMC Infectious Diseases, 2017
Background Environmental cleanliness is one of the contributing factors for surgical site infections in the operating rooms (ORs). To decrease environmental contamination, pulsed xenon ultraviolet (PX-UV), an easy and safe no-touch disinfection system ...
Lynn El Haddad, Shashank S. Ghantoji, Mark Stibich, Jason B. Fleming, Cindy Segal, Kathy M. Ware, Roy F. Chemaly   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Long-term safety and effectiveness of lurasidone in adolescents and young adults with schizophrenia: pooled post hoc analyses of two 12-month extension studies

Annals of General Psychiatry
Background and Objectives The aim of this analysis was to evaluate the long-term safety and effectiveness of lurasidone in the treatment of schizophrenia in adolescents and young adults (13–25).
Fabrizio Calisti, Michael Tocco, Yongcai Mao, Robert Goldman   +3 more
doaj   +1 more source