Results 41 to 50 of about 503,630 (310)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of Pharmacy and Bioallied SciencesThis research paper examines the implementation of employee wellness programs (EWPs) in corporate environments, assessing their impact on organizational performance, employee productivity, and workplace culture.
Shweta Soni +5 more
doaj +1 more source
Workers' Participation in Europe: Challenges facing the European policy of the European Parliament and the European Commission for 2014 and subsequent years [PDF]
, 2014 - The economic and financial crisis has raised questions about the meaning and purpose of corporate governance. After the manifest failure of the economic-liberal "shareholder value" model, a new model of "good corporate governance" deserves a closer ...
Emons, Oliver +5 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Work-related experiences of prostate cancer survivors in Australia: a qualitative study
BMC Public Health, 2023 Background Prostate cancer (PCa) is the most diagnosed cancer in Australian men, and the number of survivors is growing with advances in diagnosis and treatment.
Wei-Hong Liu, Jennifer Fox, Patsy Yates
doaj +1 more source
Employee participation in Europe:in search of the high participative workplace in Europe [PDF]
, 2001 This report presents an overview of practices on participation schemes in companies in different European countries. It is based on a secondary analysis of the 1996 EPOC-mail survey data among managers of profit-sector establishments in ten EU countries.
Hendrickx, John +2 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
The Relationship Between Employee Satisfaction and Perceived Organizational Performance
Administrative SciencesEmployee satisfaction remains a central theme in management, with substantial evidence linking it to organizational performance. This study examines the nature and strength of that relationship and investigates whether its magnitude varies across ...
Magnus Haukur Asgeirsson +2 more
doaj +1 more source
Organizational Renewal: The Management of Large-Scale Organizational Change in Norwegian Firms [PDF]
, 1994 A study of large organizational change projects was done in 228 private and public sector firms across Norway to examine the causes and consequences of renewal efforts and the strategies used by firm level management and union leaders to involve the ...
Hammer, Tove H. +3 more
core +2 more sources