Results 121 to 130 of about 19,080,997 (296)

Measuring Occupational Well-Being Indicators: Scale Construction and Validation

Behavioral Sciences
The purpose of this study is to carry out the scale development of occupational well-being (OWB) (affective, professional, social, cognitive, psychological and psychosomatic well-being) in Laos.
Hanvedes Daovisan, Ungsinun Intarakamhang   +1 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Employee owned businesses - access to funding [PDF]

, 2014
This report presents findings from a research project concerning access to funding for employee-owned businesses (EOBs) in Scotland. The two main objectives were: first, to examine the role of funding for firms moving into employee ownership - especially
Brown, Ross Crawford, Summers, Juliette, Mawson, Suzanne, Brown, Ross, McQuaid, Ronald, Summers, Juliette Clair, McQuaid, Ron   +6 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Is Psychological Well-being Linked to the Consumption of Fruit and Vegetables? [PDF]

, 2012
Humans run on a fuel called food. Yet economists and other social scientists rarely study what people eat. We provide simple evidence consistent with the existence of a link between the consumption of fruit and vegetables and high well-being.
Blanchflower, David, Stewart-Brown, Sarah, Oswald, Andrew J, Oswald, Andrew J., Blanchflower, David G., Stewart-Brown, Sarah L.   +5 more
core  

Navigating Employee Well-Being in the Age of Digital Transformation: A PRISMA-Based Systematic Review

Societies
Digital transformation constantly changes the work practices and employee experiences of contemporary work environments. Studies have documented the adverse impact of cutting-edge technologies, such as artificial intelligence, algorithmic systems, and ...
Sharmila Rani Moganadas, Gerald Guan Gan Goh, Chew Sze Cheah, Guruh Fajar Shidik   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Latent Class Analysis of Environmental Behavior and Psychological Well-Being: Insights into Sustainable Well-Being Practices

This study explores the relationship between environmental behavior, job satisfaction, performance, and burnout using latent class analysis (LCA) to identify distinct behavioral patterns.
Ayşe Bostan, Yavuz Selim Balcıoğlu, Meral Elçi   +2 more
core   +1 more source

Assessing Work-Related Employee Well-Being in Multinational Corporations Using a Multifaceted Approach

Psychological Test Adaptation and Development
: Despite growing interest in employee well-being, the field lacks work-related well-being measures suitable for use in multinational corporations where English is the lingua franca. To address this gap, we assessed the structural and convergent validity
Serkan Deveci, Anu Realo
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source