Results 221 to 230 of about 1,042,888 (318)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Factors influencing the decision to opt out of basic medical insurance among China's migrant population: a logistic regression analysis. [PDF]

Front Public Health
Li X, Zuo H, Li M.
europepmc   +1 more source

Reducing Friction in Employer-Employee Relationships [PDF]

, 1947
Selekman, Benjamin M., Selekman, Sylvia K.   +1 more
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Uptake and engagement with digital mental health in the workplace: A mixed-methods analysis of the EMPOWER trial. [PDF]

Internet Interv
Peeters SB, de Mul M, Thielen FW, Sinokki M, Staszewska K, Salvador-Carulla L, Lukersmith S, Olaya B, Hakkaart-van Roijen L.   +8 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The ADAPT model: integrating employer insights into a framework for practice-ready health professions graduates. [PDF]

BMC Med Educ
Stubbs MA, Guppy M, Onifade O, Mwangi F, Wynne K, Burrows J, Bembridge E, Aulsebrook N, Majeed T, Malau-Aduli BS, ACHIEVE Network.   +10 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Stakeholder perceptions of supporting patients' return to work in primary care: a qualitative study. [PDF]

BJGP Open
Harrison R, Wynne Jones G, Parsons V, Madan I, Chew-Graham CA, Pemberton J, Mansell G, Walker-Bone K, Foster NE, Saunders B, wider WAVE trial team.   +10 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source