Results 191 to 200 of about 81,683 (267)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A systematic model for health systems to prevent and respond to health emergencies in the workplace. [PDF]

BMC Health Serv Res
Farshad AA, Yarmohammadi S, Motalebi Gh M, Hassanzadeh-Rangi N, Faghihi M, Ezati E, Khosravi Y.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Genetic counselors' perspectives and experiences with workplace genetic testing: Results of a national survey. [PDF]

Genet Med Open
Truhlar A, Charnysh E, Pal S, Reader JM, Hendy K, Feero WG, Ryan K, Vogle A, McCain S, Ferber RA, Furnival J, Lee C, Roberts JS, Uhlmann WR, Sanghavi K, INSIGHT @ Work Consortium.   +15 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

(Mis)alignment of employer support and needs of healthcare providers in end-of-life care during a healthcare crisis: a longitudinal mixed-method study during the COVID-19 pandemic (the CO-LIVE study). [PDF]

Palliat Care Soc Pract
Zee MS, Pasman HR, Witkamp E, Becqué YN, Goossensen A, Onwuteaka-Philipsen BD.   +5 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Digital footprints and recruitment: an experimental study on the impact of social media content on hiring decisions. [PDF]

Front Psychol
Türker N, Üngüren E.
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Opportunities for employers to address the opioid epidemic: results from a national survey. [PDF]

Health Aff Sch
SteelFisher GK, Castrucci BC, Findling MG, Prus EC, Sutton J, Barnett ML.   +5 more
europepmc   +1 more source