Results 41 to 50 of about 153,012 (307)

Employment and Handicap, 1989

open access: yes, 1995
copyright UK Data Service and data collection copyright owner.The aim of this survey was to estimate the size and regional distribution of the British population of people registerable under the Disabled Persons (Employment) Act 1944; to estimate the ...
Employment Department, Disability Services Branch   +1 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Understanding the meaning of politicisation of hte employment relationship through historical analysis [PDF]

open access: yes, 2010
For more than one hundred years, Australian governments have supported the principle that the employment relationship of public servants should be independent of direct control by politicians.
Haidar, A, Spooner, KB
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Medical Specialization Exam in the Field of Child Health and Diseases Quota and Placement Trend Analysis (2013-2023)

open access: yesForbes Tıp Dergisi
Objective: This study aims to analyze the impact of changes in Medical Specialization Exam (TUS) quotas between 2013 and 2023 on occupancy rates across branches, focusing specifically on the specialization of pediatrics.
Mehmet KOCA
doaj   +1 more source

Guaranteed Employment Plans

open access: yesLaw and Contemporary Problems, 1936
The mere mention of guaranteed employment is likely to excite widespread interest and support from those persons and groups who desire, through the enactment of state unemployment compensation laws, to prevent unemployment as well as to alleviate its effects.
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Optimizing Data Interoperability: An Approach Towards Unified Employment Data in Indonesia [PDF]

open access: yesSHS Web of Conferences
This research focuses on efforts to optimize data interoperability towards unified employment data in Indonesia, which consists of planning, manufacturing, integration, and marketing strategies using the Twitter social media account @kemnakerRI, which ...
Wahyuni Herpita   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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