Results 201 to 210 of about 1,336,195 (329)

Dog Owners Exhibit Better Diet Quality but Similar Physical Activity Compared to Non-Owners: A Case-Control Study. [PDF]

Nutrients
Margaritis KL, Perantonaki M, Pyrga K, Pardali EC, Poulimeneas D, Goulis DG, Tsigga M, Grammatikopoulou MG.   +7 more
europepmc   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Does the nature of solid feed influence rumen development? A comparative study of calves fed a high milk replacer with starter concentrate or alfalfa hay. [PDF]

Braz J Vet Med
Vazquez N, Dos Santos D, Artigas R, Antúnez G, Amaro N, López M, Mas R, Cajarville C.   +7 more
europepmc   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Prevalence and characteristics of bladder wall thickening in dogs without lower urinary tract disease: an ultrasonographic study. [PDF]

Front Vet Sci
François C, Billen F, Noël S, Etienne AL, Seidel L, Bolen G.   +5 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Novel behavioral tasks for the measurement of social motivation in mice: a comparison across strains. [PDF]

Front Behav Neurosci
Wells C, Huddleston KP, Brown S, Razzaq F, Chick D, Rogers TD.   +5 more
europepmc   +1 more source

Characterization of relative growth of empty body and carcass components for bulls from a five-breed diallel.

Journal of Animal Science, 1991
J. F. Baker, W. Bryson, J. Sanders, P. F. Dahm, T. C. Cartwright, W. C. Ellis, C. R. Long   +6 more
semanticscholar   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Feasibility of the heaviness perception test as an assessment of interoception. [PDF]

Biopsychosoc Med
Fujimoto D, Sakakibara M.
europepmc   +1 more source