Results 21 to 30 of about 62,727 (249)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Pre-hospital cardiac arrest: a call for moral agency in modern medical practice

BMC Medical Ethics
This article features an exemplary case of a terminally ill man with a do-not-resuscitate (DNR) order who is subject to a resuscitation attempt after suffering an out-of-hospital cardiac arrest (OHCA).
Christina Louise Joerck, Alexander Sejr Skovbo Kristensen, Martin Holdgaard Lunding, Lars Grassmé Binderup, Lotte Huniche, Mette Aaby Smith, Søren Mikkelsen, Henriette Bruun   +7 more
doaj   +1 more source

Hemorrhagic pseudo-cystic transformation of a sequestered lumbar disc fragment mimicking a synovial cyst

Interdisciplinary Neurosurgery
Background: Lumbar synovial cysts are most common in older adults, especially females, often associated with degenerative spine changes like facet joint arthritis and instability.
Alaa Eldin Elsharkawy, Evariste Gafumbegete, Peter Douglas Klassen   +2 more
doaj   +1 more source

Searching for a long-acting injectable formulation for the antiretroviral dolutegravir

British Journal of Pharmacy, 2019
The aim of this study was to engineer a DTG particle size able to provide plasma drug concentration maintenance above PA-IC-90 and, based on such drug prolonged- exposure, to evaluate the 30 days-acting injectable DTG feasibility for anti-HIV therapy ...
Anderson Aparecido de Marchi , Claudia Bandeira Kobarg , Keity Margareth Doretto , Luis Gustavo Robello, Maiara Cássia Pigatto, Marilene Alves, Renar Pereira Santos Pereira   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

EFFECT OF ETHYL METHANE SULPHONATE ON IMPROVING THE PHYSIOLOGICAL AND BIOCHEMICAL PROPERTIES OF TWO STRAWBERRY CULTIVARS [PDF]

مجلة الأنبار للعلوم الزراعية
A study was conducted in the laboratory of plant tissue culture in the College of Agriculture / University of Anbar to determine the effect of four concentrations of ethyl methane sulfonate (EMS) 0, 1, 2 and 3% on the biochemical characteristics of two ...
R. E. Y. AL-Hayali, S. I. Neamah
doaj   +1 more source

The Application of Energy Management Systems Using the Internet of Things to Improve the Efficiency of Electrical Energy Usage in the MSMEs Sector

Protek: Jurnal Ilmiah Teknik Elektro, 2023
Monitoring the electrical energy of the MSME sector is necessary because the current use of electricity is less effective and consumes more electrical power. The use of electrical power can only be seen through the kWh meter measuring instrument and only
Erick Sorongan, riklan kango, Suhaedi Suhaedi   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source