Results 101 to 110 of about 366,025 (373)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Reconfigurable photonic generation of broadband chirped waveforms using a single CW laser and low-frequency electronics

open access: yesNature Communications, 2018
Producing versatile radio-frequency chirped waveforms often requires complicated techniques. The authors use a fiber-optic frequency-shifting loop to create a low-complexity photonic chirp generator with high bandwidth and fully flexible properties for ...
Hugues Guillet de Chatellus   +4 more
doaj   +1 more source

Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest [PDF]

open access: yes, 2007
The neural crest, a transient population of migratory cells, forms the craniofacial skeleton and peripheral nervous system, among other derivatives in vertebrate embryos. The transcriptional repressor Snail2 is thought to be crucial for the epithelial-to-
Bronner-Fraser, Marianne   +2 more
core   +1 more source

Photo‐Switching Thermal and Lithium‐Ion Conductivity in Azobenzene Polymers

open access: yesAdvanced Functional Materials, EarlyView.
Light‐responsive azobenzene polymers control thermal and ionic transport simultaneously through structural transitions. UV illumination disrupts π–π stacking, converting crystalline trans states to amorphous cis configurations. Thermal conductivity drops from 0.45 to 0.15 W·m−1·K−1 while Li+ diffusivity increases 100 fold. This dual transport switching
Jaeuk Sung   +7 more
wiley   +1 more source

Extensions of Effective Medium Theory of Transport in Disordered Systems [PDF]

open access: yes, 2008
Effective medium theory of transport in disordered systems, whose basis is the replacement of spatial disorder by temporal memory, is extended in several practical directions.
Kalay, Z., Kenkre, V. M., Parris, P. E.
core   +3 more sources

EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer

open access: yesNature, 2015
Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis despite current best therapies; therefore new treatment strategies are urgently required. Numerous studies have suggested that epithelial-to-mesenchymal transition
Xiaofeng Zheng   +8 more
semanticscholar   +1 more source

Mesoporous Carbon Thin Films with Large Mesopores as Model Material for Electrochemical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Mesoporous carbon thin films possessing 70 nm mesopores are prepared on titanium substrates by soft templating of resol resins with a self‐synthesized poly(ethylene oxide)‐block‐poly(hexyl acrylate) block copolymer. A strategy to avoid corrosion of the metal substrate is presented, and the films are extensively characterized in terms of morphology ...
Lysander Q. Wagner   +9 more
wiley   +1 more source

Probing microtubules polarity in mitotic spindles in situ using Interferometric Second Harmonic Generation Microscopy

open access: yesScientific Reports, 2017
The polarity of microtubules is thought to be involved in spindle assembly, cytokinesis or active molecular transport. However, its exact role remains poorly understood, mainly because of the challenge to measure microtubule polarity in intact cells.
S. Bancelin   +5 more
doaj   +1 more source

Equivalence of Effective Medium and Random Resistor Network models for disorder-induced unsaturating linear magnetoresistance

open access: yes, 2017
A linear unsaturating magnetoresistance at high perpendicular magnetic fields, together with a quadratic positive magnetoresistance at low fields, has been seen in many different experimental materials, ranging from silver chalcogenides and thin films of
Adam, Shaffique   +4 more
core   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

open access: yesAdvanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao   +20 more
wiley   +1 more source

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