Results 91 to 100 of about 187,158 (266)
Matrix Stiffness Directs Stemness Signatures in Breast Cancer
Advanced Healthcare Materials, EarlyView.We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky +4 more
wiley +1 more source
Mechanochemical alterations in lung cells during fibrogenesis
, 2009 Màster en BiofísicaIdiopath pulmonary fibrosis (IPF) is a usually fatal disease associated with hardening of the lung tissue, epithelial injury and abnormal wound healing.
Pavelescu, Irina
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Fabrication Error Modeling and Analysis of an
IEEE AccessThis study models and analyses the fabrication errors of an ultra-wideband (UWB) Schottky diode power detector using miniature hybrid-microwave integrated-circuit (MHMIC) technology.
Mehrdad Harifi-Mood +6 more
doaj +1 more source
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Dynamics based control with PSRs
, 2008 We present an extension of the Dynamics Based Control (DBC) paradigm to environment models based on Predictive State Representations (PSRs). We show an approximate greedy version of the DBC for PSR model, EMT-PSR, and demonstrate how this algorithm can ...
Rabinovich, Zinovi +2 more
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APL Photonics, 2019 The accurate determination of the photothermal response of nanomaterials represents an essential aspect in many fields, such as nanomedicine. Specifically, photothermal cancer therapies rely on the precise knowledge of the light-to-heat transfer ...
H. Breitenborn +11 more
doaj +1 more source
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
A 3D In Vitro Model of the Human Hepatobiliary Junction
Advanced Science, EarlyView.A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield +13 more
wiley +1 more source
Coordination and Multi-Tasking Using EMT
We introduce a multi-model variant of the EMT-based control algorithm. The new algorithm, MM-EMT, is capable of balancing several control tasks expressed using separate dynamic models with a common action space.
Rabinovich, Zinovi +2 more
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