Results 71 to 80 of about 303,325 (299)
EMT and tumor metastasis [PDF]
Clinical and Translational Medicine, 2015 AbstractEMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis.
Heerboth, Sarah +7 more
openaire +4 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics
Pharmaceutics, 2019 Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides ...
Esen Sokullu +2 more
doaj +1 more source
, 2010 The work of Emergency Medical Technicians (EMTs) is often the difference between life and death for a patient. EMTs respond to various medical emergencies including car accidents, heart attacks, slips and falls of the elderly, childbirth, and gunshot ...
Mietlicki, Robert
core +1 more source
Vacuum Energy and Casimir Force in a Presence of Skin-depth Dependent Boundary Condition [PDF]
, 2000 The vacuum energy-momentum tensor (EMT) and the vacuum energy corresponding to massive scalar field on $\Re_{t}\times [0,l] \times \Re^{D-2}$ space-time with boundary condition involving a dimensional parameter ($\delta$) are found.
Lebedev, S. L.
core +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Coupling-Strength-Independent Long-Period Grating Designs for THz-Bandwidth Optical Differentiators
IEEE Photonics Journal, 2013 A novel design of THz-bandwidth all-optical arbitrary-order temporal differentiators using long period fiber/waveguide gratings (LPGs) is proposed and numerically demonstrated.
Reza Ashrafi, Ming Li, Jose Azana
doaj +1 more source
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 2017 Very recently, the authors of [PRL {\bf 118} (2017) 021102] have shown that violation of energy-momentum tensor (EMT) could result in an accelerated expansion state via appearing an effective cosmological constant, in the context of unimodular gravity ...
Shabani, Hamid, Ziaie, Amir Hadi
core +1 more source