Results 71 to 80 of about 187,158 (266)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
The role of the cell adhesion molecule NCAM and the transcription factor Dlx2 in epithelial-mesenchymal transition (EMT) and tumor progression [PDF]
, 2009 Cancer belongs to the most life-threatening diseases in humans and represents in a simplified manner the destruction of healthy tissue and organs by uncontrolled cell proliferation and subsequent formation of a tumor.
Yilmaz, Mahmut
core +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
EMT-related genes and proteins expression were verified.
(A) Effect of POLG2 knockdown by Si RNA mix (S1, S2) on the mRNA expression of EMT markers. E-cadherin, Vimentin, α-SMA, and upstream transcription factor ZEB-1, ZEB-2.
Chuang Wu (223990) +4 more
core +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Laser-driven proton sources for efficient radiation testing
Scientific ReportsSeveral fields such as particle physics, space exploration, and high-energy physics, use Commercial Off-The-Shelf (COTS) electronic components in a high-radiation operative environment.
Beatrice D’Orsi +20 more
doaj +1 more source
Nature Communications, 2020 Real-time dynamic Fourier analysis of high-speed signals is difficult using either digital or analog schemes. Here, the authors present a universal analog approach that can track the changing frequency spectrum of waveforms in a real-time fashion at the ...
Saikrishna Reddy Konatham +7 more
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Role of DNMT3s and miR-29 family members in TGF-β mediated EMT
, 2013 Differentiated cells maintain specific programs while retain the ability to respond to environmental changes. In epithelial cells the execution of specific functions pairs the capacity to respond to stimuli that may cause dramatic variations of gene ...
AMICONE, Laura +5 more
core