Results 51 to 60 of about 187,158 (266)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Intrinsic Flexibility of the EMT Zeolite Framework Under Pressure
, 2019 The roles of organic additives in the assembly and crystallisation of zeolites is still not fully understood. This is important when attempting to prepare novel frameworks to produce new zeolites.
Mero-Lee U., Cornelius +8 more
core +1 more source
MSPB: a longitudinal multi-sensor dataset with phenotypic trait measurements from honey bees
Scientific DataWe present a one-year-long multi-sensor dataset collected from honey bee colonies (Apis mellifera) with rich phenotypic measurements. Data were collected non-stop from April 2020 to April 2021 from 53 hives located at two apiaries in Québec, Canada.
Yi Zhu +6 more
doaj +1 more source
Nature Communications, 2018 Producing versatile radio-frequency chirped waveforms often requires complicated techniques. The authors use a fiber-optic frequency-shifting loop to create a low-complexity photonic chirp generator with high bandwidth and fully flexible properties for ...
Hugues Guillet de Chatellus +4 more
doaj +1 more source
Single-pixel terahertz imaging: a review
Opto-Electronic Advances, 2020 This paper is devoted to reviewing the results achieved so far in the application of the single-pixel imaging technique to terahertz (THz) systems. The use of THz radiation for imaging purposes has been largely explored in the last twenty years, due to ...
Zanotto Luca +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Remodelling the malignant phenotype : impact of EMT
, 2009 Epithelial to mesenchymal transition (EMT) is a highly\ud conserved programme of events essential for normal\ud development. As it underpins cell plasticity, migration\ud and invasion in a number of settings it is an attractive\ud concept to apply to the
Williams, Elizabeth D. +1 more
core +1 more source
Coupling-Strength-Independent Long-Period Grating Designs for THz-Bandwidth Optical Differentiators
IEEE Photonics Journal, 2013 A novel design of THz-bandwidth all-optical arbitrary-order temporal differentiators using long period fiber/waveguide gratings (LPGs) is proposed and numerically demonstrated.
Reza Ashrafi, Ming Li, Jose Azana
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics
Pharmaceutics, 2019 Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides ...
Esen Sokullu +2 more
doaj +1 more source