Results 41 to 50 of about 303,325 (299)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic algorithm-enhanced microcomb state generation

Communications Physics
Microcavities enable the generation of highly efficient microcombs, which find applications in various domains, such as high-precision metrology, sensing, and telecommunications.
Celine Mazoukh, Luigi Di Lauro, Imtiaz Alamgir, Bennet Fischer, Nicolas Perron, A. Aadhi, Armaghan Eshaghi, Brent E. Little, Sai T. Chu, David J. Moss, Roberto Morandotti   +10 more
doaj   +1 more source

Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways [PDF]

, 2019
The epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) control the epithelial-to-mesenchymal transition (EMT) splicing program in cancer. However, their role in breast cancer recurrence is unclear. In this study, we report that high levels
Badve, Sunil S., Goswami, Chirayu P., Gu, Xiaoping, Gu, Yuan, Gökmen‐Polar, Yesim, Janga, Sarath C., Nallamothu, Gouthami, Neelamraju, Yaseswini, Ryan, Michael, Vieth, Edyta   +9 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Spectrally resolved wave-mixing between near- and far-infrared pulses in gas

New Journal of Physics, 2013
We investigate the nonlinear wave-mixing in gases between intense, short optical pulses and long-wavelength fields (mid infrared and terahertz). We show numerically that the beating between the sum- and difference-frequency generation components can be ...
M Clerici, D Faccio, L Caspani, M Peccianti, O Yaakobi, B E Schmidt, M Shalaby, F Vidal, F Légaré, T Ozaki, R Morandotti   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Invited Article: Ultra-broadband terahertz coherent detection via a silicon nitride-based deep sub-wavelength metallic slit

APL Photonics, 2018
We present a novel class of CMOS-compatible devices aimed to perform the solid-state-biased coherent detection of ultrashort terahertz pulses, i.e., featuring a gap-free bandwidth at least two decades-wide.
A. Tomasino, R. Piccoli, Y. Jestin, S. Delprat, M. Chaker, M. Peccianti, M. Clerici, A. Busacca, L. Razzari, R. Morandotti   +9 more
doaj   +1 more source

Why Effective Medium Theory Fails in Granular Materials

, 1999
Experimentally it is known that the bulk modulus, K, and shear modulus, \mu, of a granular assembly of elastic spheres increase with pressure, p, faster than the p^1/3 law predicted by effective medium theory (EMT) based on Hertz-Mindlin contact forces ...
A. V. Tkachenko, C. Thornton, D. J. Durian, David L. Johnson, G. S. Grest, Hernán A. Makse, J. D. Goddard, K. L. Johnson, K. Walton, Lawrence M. Schwartz, M. E. Cates, M.-D. Lacasse, Nicolas Gland, P. A. Cundall, P. A. Cundall, P. J. Digby, P.-G. de Gennes, S. Alexander, S. F. Edwards, S. N. Domenico, S. Roux, X. Jia   +21 more
core   +1 more source

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source