Results 101 to 110 of about 303,325 (299)

EMT in immuno-resistance

Oncoscience, 2015
Although the advent of new immunotherapy approaches has improved survival for many patients with advanced malignancies, the high degree of non-responders, especially in highly prevalent malignancies including breast, colon and prostate cancers was also a strong reminder that we possess only partial understanding of the events underlying the immune ...
Stéphane, Terry, Salem, Chouaib
openaire   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Agile manipulation of the time-frequency distribution of high-speed electromagnetic waves

Nature Communications
Controlling the temporal evolution of an electromagnetic (EM) wave’s frequency components, the so-called time-frequency (TF) distribution, in a versatile and real-time fashion remains very challenging, especially at the high speeds (> GHz regime ...
Xinyi Zhu, Benjamin Crockett, Connor M. L. Rowe, Hao Sun, José Azaña   +4 more
doaj   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Data-Aided Maximum Likelihood Joint Angle and Delay Estimator Over Orthogonal Frequency Division Multiplex Single-Input Multiple-Output Channels Based on New Gray Wolf Optimization Embedding Importance Sampling

Sensors
In this paper, we propose a new data-aided (DA) joint angle and delay (JADE) maximum likelihood (ML) estimator. The latter consists of a substantially modified and, hence, significantly improved gray wolf optimization (GWO) technique by fully integrating
Maha Abdelkhalek, Souheib Ben Amor, Sofiène Affes   +2 more
doaj   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Bioelectrical Interfaces Beyond Excitable Cells: Cancer, Aging, and Gene Expression Modulation

Advanced Materials Interfaces, EarlyView.
ABSTRACT The investigation of biological conductivity has evolved from its classical foundation based on ionic fluxes underpinning cardiac and neuronal excitability to a multifaceted regulator of cellular physiology. Traditional approaches for probing electrical events in living matter focused largely on action potentials recording.
Paolo Cadinu, Matthew K. Burgess, Catarina Franco Jones, Marzia Iarossi, Manuel Schröter, Nako Nakatsuka, Mustafa B. A. Djamgoz, Gil Gonçalves, Sidahmed Abayzeed, Paola Sanjuán‐Alberte, Paula M. Mendes, Frankie J. Rawson, Malavika Nair, Michael Levin, Rosalia Moreddu   +14 more
wiley   +1 more source

Guided-Wave Properties of Mode-Selective Transmission Line

IEEE Access, 2018
The so-called mode-selective transmission line or simply “MSTL” is studied theoretically and experimentally. This low-loss and low-dispersion transmission line operates with a frequency-dependent mode-switching behavior.
Faezeh Fesharaki, Tarek Djerafi, Mohamed Chaker, Ke Wu   +3 more
doaj   +1 more source

Meta-Analysis of EMT Datasets Reveals Different Types of EMT

PLOS ONE, 2016
As a critical process during embryonic development, cancer progression and cell fate conversions, epithelial-mesenchymal transition (EMT) has been extensively studied over the last several decades. To further understand the nature of EMT, we performed meta-analysis of multiple microarray datasets to identify the related generic signature. In this study,
Lining Liang, Hao Sun, Wei Zhang, Mengdan Zhang, Xiao Yang, Rui Kuang, Hui Zheng   +6 more
openaire   +4 more sources