Results 111 to 120 of about 303,325 (299)

Direct Mode‐Resolved Measurement of Interfacial Phonon Transport by Acoustic Phonon Reflectometry

Advanced Materials Interfaces, EarlyView.
We introduce a novel analysis, acoustic phonon reflectometry, that measures the mode‐resolved phonon reflection coefficient at semiconductor interfaces. In aluminum nitride, we observe excellent agreement with the acoustic mismatch model across three distinct interfaces.
Christopher Hennighausen, Gustavo A. Alvarez, Jeffrey Z. Kaaret, Patrick Soucy, Amir F. Amhaz, Jeffrey Moses, Kenneth R. Beyerlein, Nicole A. Benedek, Zhiting Tian, Ankit S. Disa   +9 more
wiley   +1 more source

Fabrication Error Modeling and Analysis of an E-Band MHMIC Balanced Power Detector

IEEE Access
This study models and analyses the fabrication errors of an ultra-wideband (UWB) Schottky diode power detector using miniature hybrid-microwave integrated-circuit (MHMIC) technology.
Mehrdad Harifi-Mood, Nima Souzandeh, Peyman PourMohammadi, Djilali Hammou, Bryan Hosein, Sonia Aissa, Serioja Ovidiu Tatu   +6 more
doaj   +1 more source

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution. [PDF]

, 2019
Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance.
Anchang, Benedict, Bendall, Sean C, Benson, Jalen A, Ignatiadis, Nikolaos, Karacosta, Loukia G, Kimmey, Samuel C, Plevritis, Sylvia K, Shrager, Joseph B, Tibshirani, Robert   +8 more
core  

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Quantifying the photothermal conversion efficiency of plasmonic nanoparticles by means of terahertz radiation

APL Photonics, 2019
The accurate determination of the photothermal response of nanomaterials represents an essential aspect in many fields, such as nanomedicine. Specifically, photothermal cancer therapies rely on the precise knowledge of the light-to-heat transfer ...
H. Breitenborn, J. Dong, R. Piccoli, A. Bruhacs, L. V. Besteiro, A. Skripka, Z. M. Wang, A. O. Govorov, L. Razzari, F. Vetrone, R. Naccache, R. Morandotti   +11 more
doaj   +1 more source

Distinguishing Mechanisms Underlying EMT Tristability

Cancer Convergence, 2017
AbstractBackground:The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue repair. EMT can also be co-opted by cancer cells to acquire metastatic potential and drug-resistance. Recent research has argued that epithelial (E) cells can undergo either a partial EMT
Jia, Dongya, Jolly, Mohit K., Tripathi, Satyendra C., Den Hollander, Petra, Huang, Bin, Lu, Mingyang, Celiktas, Muge, Ramirez-Peña, Esmeralda, Ben-Jacob, Eshel, Onuchic, José Nelson, Hanash, Samir M., Mani, Sendurai A., Levine, Herbert   +12 more
openaire   +5 more sources

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Millimeter-Wave Joint Sensing and Communication System Design for Connected Automated Vehicles

IEEE Access
This paper introduces a novel mmWave joint radar and communication (JRC) system operating in the 24 GHz ISM band, specifically designed for automated connected vehicles. The system utilizes a single transceiver platform featuring a frequency-shift keying
Nima Souzandeh, Mehrdad Harifi-Mood, Sonia Aissa, Serioja Ovidiu Tatu   +3 more
doaj   +1 more source