Results 131 to 140 of about 303,325 (299)

Space-time couplings in ultrashort lasers with arbitrary nonparaxial focusing

Nanophotonics
Space-time separability is commonly assumed in the theoretical description of laser beams. However, recent progresses have demonstrated that this assumption often breaks down for ultrashort realistic pulses, giving rise to spatio-temporal effects that ...
Jolly Spencer W., Lytova Marianna, Vallières Simon, Légaré François, MacLean Steve, Fillion-Gourdeau François   +5 more
doaj   +1 more source

Speaker Diarization: A Review of Objectives and Methods

Applied Sciences
Recorded audio often contains speech from multiple people in conversation. It is useful to label such signals with speaker turns, noting when each speaker is talking and identifying each speaker.
Douglas O’Shaughnessy
doaj   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

Direct Observation of Carbonate Chemisorption on Barium Titanate Surfaces by Tip‐Enhanced Raman Spectroscopy

Advanced Materials Interfaces
Surface chemistry significantly influences the physicochemical and functional properties of nanoparticles, thus necessitating the investigation of surfaces, especially when subjected to chemisorption.
Mohammad Bakhtbidar, Ifeanyichukwu Amaechi, Andreas Dörfler, Alexandre Merlen, Andreas Ruediger   +4 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Self‐Recovery of Carbonate‐Contaminated Strontium Titanate (100) Vicinal Surfaces Imaged by Tip‐Enhanced Raman Spectroscopy

Advanced Materials Interfaces
Strontium titanate (SrTiO3) as a model perovskite has significant applications in catalysis, carbon capture, and advanced electronics. On SrO‐terminated (100) surfaces, carbon dioxide (CO2) is a common chemisorption, altering the electronic and chemical ...
Mohammad Bakhtbidar, Daniel Gueckelhorn, Marivi Fernández‐Serra, Yon Leandro Leibas López, Alexandre Merlen, Andreas Ruediger   +5 more
doaj   +1 more source

Integration of Carbon Nanotubes into Manganese Dioxide Nanorods for Enhanced Enzymeless Electrochemical Glucose Sensing with High Sensitivity and Selectivity

Biosensors
Freestanding electrode designs, cost-effective catalysts, and enhanced electrical conductivity are crucial for improving the performance of fourth-generation non-enzymatic glucose electrochemical sensors.
Khawtar Hasan Ahmed, Alonso Moreno Zuria, Mohamed Mohamedi   +2 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source