Results 141 to 150 of about 155,293 (266)

Oncogenic cell fate decision in breast epithelial cells I: growth factors and mechanisms [PDF]

Res Sq
Murali D, Gupta S, Subramaniam S.
europepmc   +2 more sources

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

HHIP's dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility. [PDF]

Proc Natl Acad Sci U S A
Deritei D, Anamika WJ, Zhou AX, Yun JH, Sauler M, Cho MH, Silverman EK, Ravasz Regan E, Glass K.   +8 more
europepmc   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Metabolic Memory-Mediated Epigenetic Regulation of EMT in Diabetic Kidney Disease: Mechanisms and Therapeutic Implications. [PDF]

Int J Mol Sci
Ran X, Xu Y, Liang R, Duan Y, Jia W, Bian Y, Li C, Zhang M.   +7 more
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Deciphering the Diagnostic and Natural Therapeutic Implications of Necrosis by Sodium Overload and NK Signatures in Endometriosis Patients. [PDF]

Int J Mol Sci
Du J, Lv Z.
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Is it time to focus on expiratory muscle training in children with asthma? A randomized controlled trial. [PDF]

Eur J Pediatr
Kaya M, Ucgun H, Gemici Karaaslan B, Kiykim A, Denizoglu Kulli H.   +4 more
europepmc   +1 more source

Ordered Hydrogen Bond Network Regulates Synergistic H and OH Spillover to Promote Alkaline Hydrogen Evolution

Advanced Energy Materials, EarlyView.
Ru─Ni nanoclusters are anchored on WC via a rapid microwave quasi‐solid‐state method to build an ordered flexible interfacial hydrogen bond network. This structure boosts water dissociation and enables barrier‐free H/OH transport via the Grotthuss mechanism, forming dual H‐to‐Ru and OH‐to‐Ni spillover pathways to overcome the key challenges of alkaline
Xiangrui Zhuge, Chengfeng Wang, Xiangrui Zhuge, Wenli Yu, Qi Wu, Weiping Xiao, Lei Wang, Tianyi Ma, Zexing Wu   +8 more
wiley   +1 more source