Results 141 to 150 of about 213,806 (248)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

Advanced Science, EarlyView.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner, Petra B. Welzel, Maximilian Fusenig, Linda Sturm, Dagmar Pette, Wolfgang Wagermaier, Claudia Fischbach, Peter Fratzl, Carsten Werner   +8 more
wiley   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Pancreatic cancer EMT‑targeted therapy: Molecular mechanisms and clinical translation (Review). [PDF]

Int J Oncol
Zhang G, Wu Y, Wei M, Huang S, Wang Q, Xie Z, Liu S, Wang J.   +7 more
europepmc   +1 more source

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Nature, 2020
I. Pastushenko, Federico Mauri, Yura Song, F. de Cock, B. Meeusen, Benjamin Swedlund, Francis Impens, Delphi Van Haver, Matthieu Opitz, M. Théry, Y. Bareche, G. Lapouge, M. Vermeersch, Yves-Rémi Van Eycke, Cédric Balsat, C. Decaestecker, Y. Sokolow, S. Hassid, A. Pérez‐Bustillo, Beatriz Agreda-Moreno, L. Ríos-Buceta, P. Jaen, P. Redondo, Ramón Sieira-Gil, J. Millán-Cayetano, Onofre Sanmatrtin, N. D’haene, V. Moers, Milena Rozzi, J. Blondeau, Sophie Lemaire, Samuel Scozzaro, V. Janssens, M. de Troya, C. Dubois, D. Perez-Morga, I. Salmon, C. Sotiriou, F. Helmbacher, C. Blanpain   +39 more
semanticscholar   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation. [PDF]

Front Immunol
Darville T, Sun X, Zhang Y, O'Connell CM, Mokashi NV, Tang W, Bhardwaj A, Duncan B, Andrews CW, Wiesenfeld HC, Zheng X.   +10 more
europepmc   +1 more source

Non-redundant functions of EMT transcription factors

Nature Cell Biology, 2019
Marc P. Stemmler, R. L. Eccles, S. Brabletz, T. Brabletz   +3 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Preoperative expiratory muscle training for swallowing function in patients with esophageal cancer undergoing esophagectomy: A randomized controlled phase II trial protocol. [PDF]

PLoS One
Mizusawa H, Noguchi M, Tamura T, Shiraishi M, Kanki K, Shiraishi O, Hiraki Y, Kato H, Higashimoto Y, Yasuda T.   +9 more
europepmc   +1 more source