Results 161 to 170 of about 338,860 (400)

CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p

Molecular Cancer, 2019
Clear cell renal cell carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer cells critically influences metastatic dissemination of cancer cells.
Lu Wang, Guang Yang, Danfeng Zhao, Jiaqi Wang, Yang Bai, Qiang Peng, Hongzhi Wang, Ruizhe Fang, Guang Chen, Zhichao Wang, Ke-liang Wang, Guangbin Li, Yinhui Yang, Ziqi Wang, Pengyu Guo, Li Peng, Da-Yong Hou, Wanhai Xu   +17 more
semanticscholar   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer [PDF]

arXiv, 2020
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal transition (EMT) plays a critical role. There is extensive cross-talk between metabolism and EMT, but how this leads to coordinated physiological changes is still uncertain ...
arxiv  

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.

Cancer Research, 2018
Twist is a critical epithelial-mesenchymal transition (EMT)-inducing transcription factor that increases expression of vimentin. How Twist1 regulates this expression remains unclear.
Jing Meng, Shuang Chen, Jing-xia Han, Baoxin Qian, Xiao-rui Wang, Wei-long Zhong, Yuan Qin, Heng Zhang, Wan-feng Gao, Yue-yang Lei, Wei Yang, Lan Yang, Chao Zhang, Hui-juan Liu, Yanrong Liu, Honggang Zhou, Tao Sun, Cheng Yang   +17 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Consequences of energy conservation violation: Late time solutions of $\Lambda(T) CDM$ subclass of $f(R,T)$ gravity using dynamical system approach

, 2017
Very recently, the authors of [PRL {\bf 118} (2017) 021102] have shown that violation of energy-momentum tensor (EMT) could result in an accelerated expansion state via appearing an effective cosmological constant, in the context of unimodular gravity ...
Shabani, Hamid, Ziaie, Amir Hadi
core   +1 more source

Pharmacological targeting of netrin-1 inhibits EMT in cancer

Nature, 2023
Justine Lengrand, I. Pastushenko, Sebastiaan Vanuytven, Yura Song, D. Venet, Rahul M. Sarate, Mélanie Bellina, V. Moers, Alice Boinet, A. Sifrim, N. Rama, Benjamin Ducarouge, J. Van Herck, C. Dubois, Samuel Scozzaro, Sophie Lemaire, Sarah Gieskes, Sophie Bonni, A. Collin, Nicolas Braissand, J. Allard, Egor Zindy, C. Decaestecker, C. Sotiriou, I. Salmon, P. Mehlen, T. Voet, A. Bernet, C. Blanpain   +28 more
semanticscholar   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Agile manipulation of the time-frequency distribution of high-speed electromagnetic waves

Nature Communications
Controlling the temporal evolution of an electromagnetic (EM) wave’s frequency components, the so-called time-frequency (TF) distribution, in a versatile and real-time fashion remains very challenging, especially at the high speeds (> GHz regime ...
Xinyi Zhu, Benjamin Crockett, Connor M. L. Rowe, Hao Sun, José Azaña   +4 more
doaj   +1 more source