Results 11 to 20 of about 338,860 (400)
Nature Reviews Cancer, 2018 Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated.
Thomas Brabletz +3 more
openaire +4 more sources
RHOJ controls EMT-associated resistance to chemotherapy
Nature, 2023 RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy.
Maud Debaugnies +17 more
semanticscholar +1 more source
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Journal of Hematology & Oncology, 2022 Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis,
Yuhe Huang, Weiqi Hong, Xiawei Wei
semanticscholar +1 more source
Cell Proliferation, 2023 Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays critical roles in cancer metastasis. Recent studies, especially those based on single‐cell sequencing, have revealed that EMT is not a binary process, but a ...
Dandan Li +7 more
semanticscholar +1 more source
Dynamic EMT: a multi‐tool for tumor progression
EMBO Journal, 2021 The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire mesenchymal features, and become motile.
S. Brabletz +3 more
semanticscholar +1 more source
A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells [PDF]
EMBO Reports, 2008 The embryonic programme ‘epithelial–mesenchymal transition’ (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc‐finger E‐box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was ...
Ulrike Burk +6 more
openalex +2 more sources
Cells, 2021 The epithelial–mesenchymal transition (EMT) is an essential event during cell development, in which epithelial cells acquire mesenchymal fibroblast-like features including reduced intercellular adhesion and increased motility.
G. Marconi +6 more
semanticscholar +1 more source
EMT and Anti-EMT Strategies in Cancer [PDF]
Journal of Cancer Therapy, 2015 This article discusses the role of epithelial mesenchymal transition (EMT) and addresses the scientific merits on epigenetic regulation of EMT. The importance of EMT as a prognostic biomarker is explored and the rationale on application of multitargeted epigenetic therapy is discussed. We describe a literature review of the epigenetic influence of such
Steven Hager +2 more
openaire +2 more sources
Enhanced laser-driven proton acceleration using nanowire targets
Scientific Reports, 2021 Laser-driven proton acceleration is a growing field of interest in the high-power laser community. One of the big challenges related to the most routinely used laser-driven ion acceleration mechanism, Target-Normal Sheath Acceleration (TNSA), is to ...
S. Vallières +10 more
doaj +1 more source
Tumor Budding: The Name is EMT. Partial EMT. [PDF]
Journal of Clinical Medicine, 2016 Tumor budding is a histological phenomenon encountered in various cancers, whereby individual malignant cells and/or small clusters of malignant cells are seen in the tumor stroma. Postulated to be mirror epithelial-mesenchymal transition, tumor budding has been associated with poor cancer outcomes.
Alexandru Grigore +4 more
openaire +4 more sources