Results 11 to 20 of about 213,806 (248)
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Journal of Hematology & Oncology, 2022 Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis,
Yuhe Huang, Weiqi Hong, Xiawei Wei
semanticscholar +1 more source
Dynamic EMT: a multi‐tool for tumor progression
EMBO Journal, 2021 The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire mesenchymal features, and become motile.
S. Brabletz +3 more
semanticscholar +1 more source
Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis
Cancers, 2021 Simple Summary Vimentin is an important filamentous protein providing structural and functional support to the cell. During initial stages of cancer development, vimentin concentration is very low, however, it increases when cancer starts to invade the ...
Saima Usman +6 more
semanticscholar +1 more source
Cells, 2021 The epithelial–mesenchymal transition (EMT) is an essential event during cell development, in which epithelial cells acquire mesenchymal fibroblast-like features including reduced intercellular adhesion and increased motility.
G. Marconi +6 more
semanticscholar +1 more source
RHOJ controls EMT-associated resistance to chemotherapy
Nature, 2023 RHOJ regulates epithelial-to-mesenchymal-transition-associated resistance to chemotherapy by enhancing the response to replicative stress and activating the DNA damage response, enabling tumour cells to rapidly repair DNA lesions induced by chemotherapy.
Maud Debaugnies +17 more
semanticscholar +1 more source
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
Molecular Cancer, 2023 Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are genetic determinants of cellular plasticity. These programs operate in physiological (embryonic development, wound healing) and pathological (organ fibrosis, cancer ...
Azamat Akhmetkaliyev +3 more
semanticscholar +1 more source
Distinct contributions of partial and full EMT to breast cancer malignancy.
Developmental Cell, 2021 Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-differentiation where cancer cells transit between various stages of an EMT continuum, including epithelial, partial EMT, and mesenchymal cell states.
Fabiana Lüönd +12 more
semanticscholar +1 more source
Transcriptional regulation of EMT transcription factors in cancer.
Seminars in Cancer Biology, 2023 The epithelial-mesenchymal transition (EMT) is one of the processes by which epithelial cells transdifferentiate into mesenchymal cells in the developmental stage, known as "complete EMT." In epithelial cancer, EMT, also termed "partial EMT," is ...
M. Saitoh
semanticscholar +1 more source
Cell Proliferation, 2023 Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays critical roles in cancer metastasis. Recent studies, especially those based on single‐cell sequencing, have revealed that EMT is not a binary process, but a ...
Dandan Li +7 more
semanticscholar +1 more source
EMT‐associated microRNAs and their roles in cancer stemness and drug resistance
Cancer Communications, 2021 Epithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant behaviors of cancers, including proliferation, invasion, and metastasis.
G. Pan +4 more
semanticscholar +1 more source